High-performance pyrite nano-catalyst driven photothermal/chemodynamic synergistic therapy for Osteosarcoma

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; pp. 141 - 19
• Main Authors: Li, Meirong, Wang, Minghua, Huang, Junfeng, Tang, Shiqi, Yang, Jingyu, Xu, Zhourui, Xu, Gaixia, Chen, Xin, Liu, Jia, Yang, Chengbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.04.2024; BioMed Central; BMC
• Subjects: Apoptosis; Biocompatibility; Bone cancer; Bone Neoplasms - drug therapy; Bone tumors; Catalysts; Catalytic activity; Cell death; Cell Line, Tumor; Chemodynamic therapy; Chemotherapy; Drug resistance; Efficiency; Fenton catalyst; Ferroptosis; Humans; Hydrogen Peroxide; Infrared lasers; Invasiveness; Iron; Iron sulfides; Irradiation; Laser radiation; Lasers; Lipids; Medical prognosis; Metastases; Nanomaterials; Nanoparticles; Near infrared radiation; Neoplasms; Osteosarcoma; Osteosarcoma - drug therapy; Photothermal Therapy; Polyethylene glycol; Pyrite; Pyrite nanoparticle; Sarcoma; Side effects; Spectrum analysis; Sulfides; Tumor cells; Tumors; China; United States > US; Japan; Photothermal therapy; Chemodynamic therapy; Fenton catalyst; Osteosarcoma; Pyrite nanoparticle

Osteosarcoma (OS) is an aggressive bone tumor with strong invasiveness, rapid metastasis, and dreadful mortality. Chemotherapy is a commonly used approach for OS treatment but is limited by the development of drug resistance and long-term adverse effects. To date, OS still lacks the curative treatme...