High-performance pyrite nano-catalyst driven photothermal/chemodynamic synergistic therapy for Osteosarcoma

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; pp. 141 - 19
• Main Authors: Li, Meirong, Wang, Minghua, Huang, Junfeng, Tang, Shiqi, Yang, Jingyu, Xu, Zhourui, Xu, Gaixia, Chen, Xin, Liu, Jia, Yang, Chengbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.04.2024; BioMed Central; BMC
• Subjects: Apoptosis; Biocompatibility; Bone cancer; Bone Neoplasms - drug therapy; Bone tumors; Catalysts; Catalytic activity; Cell death; Cell Line, Tumor; Chemodynamic therapy; Chemotherapy; Drug resistance; Efficiency; Fenton catalyst; Ferroptosis; Humans; Hydrogen Peroxide; Infrared lasers; Invasiveness; Iron; Iron sulfides; Irradiation; Laser radiation; Lasers; Lipids; Medical prognosis; Metastases; Nanomaterials; Nanoparticles; Near infrared radiation; Neoplasms; Osteosarcoma; Osteosarcoma - drug therapy; Photothermal Therapy; Polyethylene glycol; Pyrite; Pyrite nanoparticle; Sarcoma; Side effects; Spectrum analysis; Sulfides; Tumor cells; Tumors; China; United States > US; Japan; Photothermal therapy; Chemodynamic therapy; Fenton catalyst; Osteosarcoma; Pyrite nanoparticle
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-024-02419-2

Osteosarcoma (OS) is an aggressive bone tumor with strong invasiveness, rapid metastasis, and dreadful mortality. Chemotherapy is a commonly used approach for OS treatment but is limited by the development of drug resistance and long-term adverse effects. To date, OS still lacks the curative treatment. Herein, we fabricated pyrite-based nanoparticles (FeS 2 @CP NPs) as synergetic therapeutic platform by integrating photothermal therapy (PTT) and chemo-dynamic therapy (CDT) into one system. The synthetic FeS 2 @CP NPs showed superior Fenton reaction catalytic activity. FeS 2 @CP NPs-based CDT efficaciously eradicated the tumor cells by initiating dual-effect of killing of apoptosis and ferroptosis. Furthermore, the generated heat from FeS 2 @CP under near-infrared region II (NIR-II) laser irradiation could not only inhibit tumor’s growth, but also promote tumor cell apoptosis and ferroptosis by accelerating •OH production and GSH depletion. Finally, the photothermal/NIR II-enhanced CDT synergistic therapy showed excellent osteosarcoma treatment effects both in vitro and in vivo with negligible side effects. Overall, this work provided a high-performance and multifunctional Fenton catalyst for osteosarcoma synergistic therapy, which provided a pathway for the clinical application of PTT augmented CDT.