Microcirculatory oxygen transport and utilization

The cardiovascular system (macrocirculation) circulates blood throughout the body, but the microcirculation is responsible for modifying tissue perfusion and adapting it to metabolic demand. Hemodynamic assessment and monitoring of the critically ill patient is typically focused on global measures o...

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Bibliographic Details
Published inCritical care nursing clinics of North America Vol. 26; no. 3; p. 311
Main Authors Hamlin, Shannan K, Parmley, C Lee, Hanneman, Sandra K
Format Journal Article
LanguageEnglish
Published United States 01.09.2014
Subjects
Hemodynamics - physiology
Humans
Microcirculation - physiology
Oxygen - blood
Oxygen - metabolism
Oxygen Consumption - physiology
Regional Blood Flow
Microcirculation
Oxygen extraction
Capillary
Oxygen utilization
Hemodynamics
Oxygen transport
Blood flow
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Summary:The cardiovascular system (macrocirculation) circulates blood throughout the body, but the microcirculation is responsible for modifying tissue perfusion and adapting it to metabolic demand. Hemodynamic assessment and monitoring of the critically ill patient is typically focused on global measures of oxygen transport and utilization, which do not evaluate the status of the microcirculation. Despite achievement and maintenance of global hemodynamic and oxygenation goals, patients may develop microcirculatory dysfunction with associated organ failure. A thorough understanding of the microcirculatory system under physiologic conditions will assist the clinician in early recognition of microcirculatory dysfunction in impending and actual disease states.
ISSN:1558-3481
DOI:10.1016/j.ccell.2014.04.006