Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization

• Published in: Fertility and sterility Vol. 95; no. 5; pp. 1816 - 1819
• Main Authors: Fujimoto, Victor Y., M.D, Kim, Dongsul, B.S, vom Saal, Frederick S., Ph.D, Lamb, Julie D., M.D, Taylor, Julia A., Ph.D, Bloom, Michael S., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2011; Elsevier
• Subjects: Adult; Benzhydryl Compounds; Biological and medical sciences; Birth control; bisphenol A; Bisphenol A (BPA); blood serum; Endocrine Disruptors - analysis; Endocrine Disruptors - blood; Endocrine Disruptors - toxicity; estrogenic properties; Female; fertilization; Fertilization - drug effects; Fertilization - physiology; Fertilization in Vitro; Gynecology. Andrology. Obstetrics; Humans; in vitro fertilization; in vitro fertilization (IVF); infertility; Infertility - etiology; Infertility - therapy; Internal Medicine; Male; Medical sciences; Obstetrics and Gynecology; oocyte maturation; oocytes; Oocytes - cytology; Oocytes - drug effects; Osmolar Concentration; Ovulation Induction - methods; patients; Phenols - analysis; Phenols - blood; Phenols - toxicity; Pregnancy; Quality Control; Sterility. Assisted procreation; women; oocyte maturation; Bisphenol A (BPA); fertilization; infertility; in vitro fertilization (IVF); Human; Fertilization; Gynecology; Assisted procreation; Concentration; Obstetrics; Sterility; In vitro fertilization embryo transfer; Quality; Female; Serum; Woman; Oocyte; Oocyte maturation
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.11.008

Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization.