Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose

Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss an...

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Published inBMC microbiology Vol. 23; no. 1; pp. 103 - 10
Main Authors Wang, Ya, Wang, Jiahui, Li, Hehai, Lao, Jianlong, Jia, Dan, Liu, Junlong, Wang, Jinming, Luo, Jianxun, Guan, Guiquan, Yin, Hong, Li, Youquan
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 15.04.2023
BioMed Central
BMC
Subjects
Aging
Aging (artificial)
Analysis
Anti-aging
Antioxidant
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Bifidobacterium - metabolism
Bifidobacterium longum
Comparative analysis
D-Galactose
Dietary supplements
Enzymes
Free radicals
Galactose
Galactose - pharmacology
Health aspects
High density lipoprotein
Humans
Lipid peroxidation
Lipids
Liver
Low density lipoprotein
Low density lipoproteins
Metabolism
Oxidative Stress
Peroxidation
Phylogenetics
Physiological aspects
Probiotics
Scavenging
Spleen
Thymus gland
Weight Loss
China
Anti-aging
Antioxidant
Bifidobacterium longum
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Summary:Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose. T37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver. T37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.
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ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-023-02846-5