Thermal gradient induced tweezers for the manipulation of particles and cells

• Published in: Scientific reports Vol. 6; no. 1; p. 35814
• Main Authors: Chen, Jiajie, Cong, Hengji, Loo, Jacky, Kang, Zhiwen, Tang, Minghui, Zhang, Haixi, Wu, Shu-Yuen, Kong, Siu-Kai, Ho, Ho-Pui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.11.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 45/62; 631/1647/277; 631/61/350/877; 639/925/350/354; Convection; Hot Temperature; Humanities and Social Sciences; Integration; Lab-on-a-chip; Lab-On-A-Chip Devices; Microfluidics; multidisciplinary; Optical Tweezers; Polystyrene; Science; Scientific apparatus & instruments; Trapping
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep35814

Optical tweezers are a well-established tool for manipulating small objects. However, their integration with microfluidic devices often requires an objective lens. More importantly, trapping of non-transparent or optically sensitive targets is particularly challenging for optical tweezers. Here, for the first time, we present a photon-free trapping technique based on electro-thermally induced forces. We demonstrate that thermal-gradient-induced thermophoresis and thermal convection can lead to trapping of polystyrene spheres and live cells. While the subject of thermophoresis, particularly in the micro- and nano-scale, still remains to be fully explored, our experimental results have provided a reasonable explanation for the trapping effect. The so-called thermal tweezers, which can be readily fabricated by femtosecond laser writing, operate with low input power density and are highly versatile in terms of device configuration, thus rendering high potential for integration with microfluidic devices as well as lab-on-a-chip systems.