Novel Lactone Compounds from Mortierella verticillata that Induce the Human Low Density Lipoprotein Receptor Gene:Fermentation, Isolation, Structural Elucidation and Biological Activities

• Published in: Journal of antibiotics Vol. 51; no. 1; pp. 14 - 20
• Main Authors: DEKKER, KOEN A., AIELLO, ROBERT J., HIRAI, HIDEO, INAGAKI, TAISUKE, SAKAKIBARA, TATSUO, SUZUKI, YUMIKO, THOMPSON, JOHN F., YAMAUCHI, YUJI, KOJIMA, NAKAO
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1998; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Biological and medical sciences; Biotechnology & Applied Microbiology; Cell Culture Techniques; Fermentation; Gene Expression Regulation; General and cellular metabolism. Vitamins; Humans; Immunology; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Life Sciences & Biomedicine; Macrolides - chemistry; Macrolides - isolation & purification; Macrolides - pharmacology; Medical sciences; Microbiology; Mucorales - chemistry; Mucorales - metabolism; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Receptors, LDL - genetics; Science & Technology; CELLS; IN-VIVO; Human; Phycomycetes; Lactone; Oxime; Gene expression; Fermentation; In vitro; Biological activity; Fungi; Lipoprotein LDL; Hepatocyte; Microorganism culture; Thallophyta; Structural analysis; Biological receptor

Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. The...