Novel Lactone Compounds from Mortierella verticillata that Induce the Human Low Density Lipoprotein Receptor Gene:Fermentation, Isolation, Structural Elucidation and Biological Activities

Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. The...

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Published inJournal of antibiotics Vol. 51; no. 1; pp. 14 - 20
Main Authors DEKKER, KOEN A., AIELLO, ROBERT J., HIRAI, HIDEO, INAGAKI, TAISUKE, SAKAKIBARA, TATSUO, SUZUKI, YUMIKO, THOMPSON, JOHN F., YAMAUCHI, YUJI, KOJIMA, NAKAO
Format Journal Article
LanguageEnglish
Published TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1998
JAPAN ANTIBIOT RES ASSN
Japan Antibiotics Research Association
Subjects
Biological and medical sciences
Biotechnology & Applied Microbiology
Cell Culture Techniques
Fermentation
Gene Expression Regulation
General and cellular metabolism. Vitamins
Humans
Immunology
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Life Sciences & Biomedicine
Macrolides - chemistry
Macrolides - isolation & purification
Macrolides - pharmacology
Medical sciences
Microbiology
Mucorales - chemistry
Mucorales - metabolism
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Receptors, LDL - genetics
Science & Technology
CELLS
IN-VIVO
Human
Phycomycetes
Lactone
Oxime
Gene expression
Fermentation
In vitro
Biological activity
Fungi
Lipoprotein LDL
Hepatocyte
Microorganism culture
Thallophyta
Structural analysis
Biological receptor
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Summary:Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100nM.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.14