NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; p. 73
• Main Authors: Li, Wenling, Xin, Huan, Gao, Wenjuan, Yuan, Pengjun, Ni, Feixue, Ma, Jingyi, Sun, Jingrui, Xiao, Jianmin, Tian, Geng, Liu, Lu, Zhang, Guilong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.02.2024; BioMed Central; BMC
• Subjects: Ablation; Angiogenesis; Anti-angiogenesis; Antigens; Antitumor immunity; Apoptosis; Biocompatibility; Blood vessels; Breast cancer; Cancer; Cancer therapies; Care and treatment; Cell death; Chelating agents; Chelation; Copper; Copper nano-reaper; Diagnosis; Electrons; Evaluation; Fluorescence; Fourier transforms; Heat; Immune system; Immunity; Immunogenicity; Ions; Irradiation; Laser radiation; Lasers; Metastases; Metastasis; Microenvironments; Nanocrystals; Nanomaterials; Nanoparticles; Near infrared radiation; PD-L1 protein; Photothermal therapy; T cell receptors; Thermal energy; Thermogravimetric analysis; Tumor cells; Tumor metastasis; Tumors; China; Photothermal therapy; Antitumor immunity; Copper nano-reaper; Anti-angiogenesis; Tumor metastasis

The formation of blood vessel system under a relatively higher Cu ion level is an indispensable precondition for tumor proliferation and migration, which was assisted in forming the tumor immune microenvironment. Herein, a copper ions nano-reaper (LMDFP) is rationally designed not only for chelating...