NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy

• Published in: Journal of nanobiotechnology Vol. 22; no. 1; p. 73
• Main Authors: Li, Wenling, Xin, Huan, Gao, Wenjuan, Yuan, Pengjun, Ni, Feixue, Ma, Jingyi, Sun, Jingrui, Xiao, Jianmin, Tian, Geng, Liu, Lu, Zhang, Guilong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.02.2024; BioMed Central; BMC
• Subjects: Ablation; Angiogenesis; Anti-angiogenesis; Antigens; Antitumor immunity; Apoptosis; Biocompatibility; Blood vessels; Breast cancer; Cancer; Cancer therapies; Care and treatment; Cell death; Chelating agents; Chelation; Copper; Copper nano-reaper; Diagnosis; Electrons; Evaluation; Fluorescence; Fourier transforms; Heat; Immune system; Immunity; Immunogenicity; Ions; Irradiation; Laser radiation; Lasers; Metastases; Metastasis; Microenvironments; Nanocrystals; Nanomaterials; Nanoparticles; Near infrared radiation; PD-L1 protein; Photothermal therapy; T cell receptors; Thermal energy; Thermogravimetric analysis; Tumor cells; Tumor metastasis; Tumors; China; Photothermal therapy; Antitumor immunity; Copper nano-reaper; Anti-angiogenesis; Tumor metastasis
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-024-02343-5

The formation of blood vessel system under a relatively higher Cu ion level is an indispensable precondition for tumor proliferation and migration, which was assisted in forming the tumor immune microenvironment. Herein, a copper ions nano-reaper (LMDFP) is rationally designed not only for chelating copper ions in tumors, but also for combination with photothermal therapy (PTT) to improve antitumor efficiency. Under 808 nm laser irradiation, the fabricated nano-reaper converts light energy into thermal energy to kill tumor cells and promotes the release of D-penicillamine (DPA) in LMDFP. Photothermal properties of LMDFP can cause tumor ablation in situ, which further induces immunogenic cell death (ICD) to promote systematic antitumor immunity. The released DPA exerts an anti-angiogenesis effect on the tumor through chelating copper ions, and inhibits the expression of programmed death ligand 1 (PD-L1), which synergizes with PTT to enhance antitumor immunity and inhibit tumor metastasis. Meanwhile, the nanoplatform can emit near-infrared-IIb (NIR-IIb) fluorescence under 980 nm excitation, which can be used to track the nano-reaper and determine the optimal time point for PTT. Thus, the fabricated nano-reaper shows powerful potential in inhibiting tumor growth and metastasis, and holds great promise for the application of copper nanochelator in precise tumor treatment.