Biological roles of SLC16A1-AS1 lncRNA and its clinical impacts in tumors

Recent studies have increasingly highlighted the aberrant expression of SLC16A1-AS1 in a variety of tumor types, where it functions as either an oncogene or a tumor suppressor in the pathogenesis of different cancers. The expression levels of SLC16A1-AS1 have been found to significantly correlate wi...

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Published inCancer cell international Vol. 24; no. 1; pp. 122 - 12
Main Authors Liao, Bing, Wang, Jialing, Yuan, Yalin, Luo, Hongliang, Ouyang, Xi
Format Journal Article
LanguageEnglish
Published England BioMed Central 30.03.2024
BMC
Subjects
Apoptosis
Biomarkers
Brain cancer
Cancer biomarker
Cancer therapies
Cell cycle
Cell growth
CRISPR
Disease
Ferroptosis
Gene expression
Glioma
Human tumor
Kidney cancer
Liver cancer
Medical prognosis
Medical research
Metabolism
MicroRNAs
Review
Roles
SLC16A1-AS1
Squamous cell carcinoma
Therapeutic targets
Tumor suppressor genes
Tumorigenesis
Tumors
Cancer biomarker
SLC16A1-AS1
Tumorigenesis
Human tumor
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Summary:Recent studies have increasingly highlighted the aberrant expression of SLC16A1-AS1 in a variety of tumor types, where it functions as either an oncogene or a tumor suppressor in the pathogenesis of different cancers. The expression levels of SLC16A1-AS1 have been found to significantly correlate with clinical features and the prognosis of cancer patients. Furthermore, SLC16A1-AS1 modulates a range of cellular functions, including proliferation, migration, and invasion, through its interactions with diverse molecules and signaling pathways. This review examines the latest evidence regarding the role of SLC16A1-AS1 in the progression of various tumors and explores its potential clinical applications as a novel prognostic and diagnostic biomarker. Our comprehensive review aims to deepen the understanding of SLC16A1-AS1’s multifaceted role in oncology, underscoring its potential as a significant biomarker and therapeutic target.
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ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-024-03285-6