Circular RNAs in Cardiovascular Disease: An Overview

Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an inc...

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Published inBioMed research international Vol. 2017; no. 2017; pp. 1 - 9
Main Authors Gan, Tianyi, Chen, Wei, Zhao, Yifan, Weng, Xinyu, Fan, Ximin, Xu, Dachun
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Biomarkers
Biosynthesis
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - pathology
Gene expression
Gene Expression Regulation
Genetic aspects
Hospitals
Humans
Methods
MicroRNAs - genetics
Open access
Proteins
Review
RNA - biosynthesis
RNA - genetics
RNA sequencing
RNA Splicing - genetics
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Summary:Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.
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Academic Editor: Xinli Li
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5135781