Deciphering post-translational modification codes

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning t...

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Bibliographic Details
Published inFEBS letters Vol. 587; no. 8; pp. 1247 - 1257
Main Authors Lothrop, Adam P., Torres, Matthew P., Fuchs, Stephen M.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 17.04.2013
Subjects
Acetylation
Binding Sites
Epigenetic
Histone
Humans
Methylation
Models, Molecular
Phosphorylation
Post-translational modification
Protein Processing, Post-Translational
Protein Structure, Tertiary
Proteins - chemistry
Proteins - metabolism
Signaling
Post-translational modification
Signaling
Phosphorylation
Epigenetic
Histone
Methylation
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Summary:Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood. This manuscript highlights several examples of combinatorial PTMs in proteins, and describes recent technological developments, which are driving our ability to understand how PTM patterns may “code” for biological outcomes.
Bibliography:ObjectType-Article-2
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ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2013.01.047