度洛西汀联合褪黑素改善抑郁症患者抑郁情绪及躯体化症状的研究

目的 探讨度洛西汀联合褪黑素对抑郁患者抑郁情绪及躯体化症状的改善情况.方法 选取2011年5月-2014年2月天津安定医院中西医结合科住院患者中符合《国际疾病分类（第10版）》（ICD-10）抑郁发作诊断标准的患者71例,采用分层随机法分为实验组36例,对照组35例.对照组患者以度洛西汀系统治疗,实验组在服用度洛西汀基础上加用褪黑素.两组患者均连续治疗8周,在入组时及治疗后2、4、8周末采用汉密顿抑郁量表24项版本（HAMD-24）及躯体化症状自评问卷（SSS）评定抑郁症状及躯体化症状.结果 治疗8周后,两组HAMD评分差异有统计学意义（t=-2.234,df=69,P=0.029）,两组SS...

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Published in四川精神卫生 Vol. 27; no. 4; pp. 314 - 316
Main Author 窦光茜 刘志东 康明秀 马静 王勇 程娟
Format Journal Article
LanguageChinese
Published 300140,天津第四中心医院精神科%天津安定医院中西医结合科 2014
Subjects
度洛西汀
抑郁
褪黑素
躯体化
躯体化
抑郁
度洛西汀
褪黑素
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Summary:目的 探讨度洛西汀联合褪黑素对抑郁患者抑郁情绪及躯体化症状的改善情况.方法 选取2011年5月-2014年2月天津安定医院中西医结合科住院患者中符合《国际疾病分类（第10版）》（ICD-10）抑郁发作诊断标准的患者71例,采用分层随机法分为实验组36例,对照组35例.对照组患者以度洛西汀系统治疗,实验组在服用度洛西汀基础上加用褪黑素.两组患者均连续治疗8周,在入组时及治疗后2、4、8周末采用汉密顿抑郁量表24项版本（HAMD-24）及躯体化症状自评问卷（SSS）评定抑郁症状及躯体化症状.结果 治疗8周后,两组HAMD评分差异有统计学意义（t=-2.234,df=69,P=0.029）,两组SSS评分差异也有统计学意义（t=-2.093,df=69,P=0.04）.结论 度洛西汀联合褪黑素能有效改善抑郁症患者的躯体化症状和抑郁情绪.
Bibliography:Objective To evaluate the effect of melatonin synergizing with duloxetine in improving the somatization symptoms and mood in patients with depressive disorder. Methods 71 subjects were enrolled in this study from the wards of Dept. Integrative Medicine in Anding hospital, form May 2011 to February 2014, who were also randomly divided into 2 groups, namely the study group and the controlled one （ 36 for study group and 35 for controlled group） ; duloxetine alone was applied for patients in controlled group, white melatonin, along with duloxetine, was for those in the study group ; patients from both groups were assessed with HAMD and SSS at start point, the end of 2 weeks and 4 weeks of treatment , also at the endpoint （8 weeks）. Results Patients form both groups were much better after 8 weeks of treatment ; those in the study group were with lower HAMD and SSS score than the controlled group. Con- clusion Melatonin synergizing with duloxetine can improve the quality of sleep and mood in patients with depressi
ISSN:1007-3256
DOI:10.3969/j.issn.1007-3256.2014.04.008