动脉瘤性蛛网膜下腔出血急性期高血糖对患者一年死亡的影响

目的探讨动脉瘤性蛛网膜下腔出血急性期血糖水平对患者长期预后的影响。方法连续入组首都医科大学附属北京天坛医院收治的发病时间在3 d内、无糖尿病病史的动脉瘤性蛛网膜下腔出血患者,分析患者入院、发病14 d空腹血糖以及血糖变化趋势。多因素Cox生存比例回归分析用以评价影响发病1年全因死亡的因素。结果239例无糖尿病病史的动脉瘤性蛛网膜下腔出血患者进入研究并最终完成全部随访。结果显示入院时空腹血糖越高的患者,1年死亡率越高[危险比(hazard ratio,HR)1.415,95%可信区间(confidence interval,CI),1.166~1.718]。发病14 d时有85例(36.80%)...

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Published in中国卒中杂志 Vol. 11; no. 11; pp. 934 - 941
Main Author 侯宗刚 陶晓刚 田润发 边立衡
Format Journal Article
LanguageChinese
Published 1100050,北京首都医科大学附属北京天坛医院神经外科%首都医科大学附属北京天坛医院神经病学中心,血管神经病学科 2016
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Summary:目的探讨动脉瘤性蛛网膜下腔出血急性期血糖水平对患者长期预后的影响。方法连续入组首都医科大学附属北京天坛医院收治的发病时间在3 d内、无糖尿病病史的动脉瘤性蛛网膜下腔出血患者,分析患者入院、发病14 d空腹血糖以及血糖变化趋势。多因素Cox生存比例回归分析用以评价影响发病1年全因死亡的因素。结果239例无糖尿病病史的动脉瘤性蛛网膜下腔出血患者进入研究并最终完成全部随访。结果显示入院时空腹血糖越高的患者,1年死亡率越高[危险比(hazard ratio,HR)1.415,95%可信区间(confidence interval,CI),1.166~1.718]。发病14 d时有85例(36.80%)患者血糖较入院时增高,146例患者血糖较入院时降低或不变,死亡患者中血糖升高比例显著高于存活患者中血糖升高的比例(61.54%vs 33.66%,P=0.006)。Cox生存比例回归分析显示发病14 d血糖升高(HR 1.317,95%CI 1.132~1.532),患者1年死亡风险越大。结论入院时空腹血糖以及发病14 d内血糖的变化是不伴糖尿病的动脉瘤性蛛网膜下腔出血患者1年死亡的独立预测因素。
Bibliography:11-5434/R
Hyperglycemia;Subarachnoid hemorrhage;Aneurysmal;Outcomes;Mortality
HOU Zong-Gang, TAO Xiao-Gang, TIAN Run-Fa, BIAN Li-Heng(Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China)
Objective To investigate the glucose level at acute phase of aneurysmal subarachnoid hemorrhage (aSAH) on long-term outcome of patients. Methods Patients who were diagnosed as aSAH without history of diabetes and admitted within 3 h after onset by Beijing Tiantan Hospital, Capital Medical University were enrolled to assess fasting glucose on admission, day 14 and their variation. Multivariate Cox regression analysis was used to assess risk factors for 1-year mortality. Results A total of 239 aSAH patients without history of diabetes were enrolled and followed up in this study. Admission glucose levels were found to be positively associated with 1-year mortality (hazard ratio [HR] 1.415, 95% conifdence interval [CI] 1.166-1.718). Within 14 days after onset of diseas
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2016.11.007