The biogenesis of chromosome translocations

Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has delineated several distinct mechanistic steps in the formation of translocations, and it has become ap...

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Bibliographic Details
Published inNature cell biology Vol. 16; no. 4; pp. 293 - 300
Main Authors Roukos, Vassilis, Misteli, Tom
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.04.2014
Subjects
Animals
Biosynthesis
Cell cycle
Cell Transformation, Neoplastic - genetics
Chromatin - genetics
Chromosome mapping
Chromosomes
DNA Breaks, Double-Stranded
DNA damage
DNA repair
DNA Repair - genetics
Genetic research
Genomes
Histones - genetics
Humans
Methods
Mice
Mutation Rate
Proteins
Radiation
Saccharomyces cerevisiae - genetics
Translocation (Genetics)
Translocation, Genetic - genetics
Tumors
Yeast
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Summary:Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has delineated several distinct mechanistic steps in the formation of translocations, and it has become apparent that non-random spatial genome organization, DNA repair pathways and chromatin features, including histone marks and the dynamic motion of broken chromatin, are critical for determining translocation frequency and partner selection.
Bibliography:ObjectType-Article-1
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ISSN:1465-7392
1476-4679
DOI:10.1038/ncb2941