The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

• Published in: Nutrition & metabolism Vol. 17; no. 1; p. 49
• Main Authors: Xu, Renying, Jiang, Xiaomin, Fan, Zhuping, Wan, Yanping, Gao, Xiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.06.2020; BioMed Central; BMC
• Subjects: Adults; Analysis; Blood glucose; Blood pressure; C-reactive protein; Cholesterol; Diabetes; Diabetes mellitus; EDTA; Fasting; Glucose; Hemoglobin; High sensitivity C-reactive protein (hs-CRP); Hypertension; Hypothesis testing; Lipoproteins; Standard deviation; Trajectory; Triglycerides; China; United Kingdom > UK; High sensitivity C-reactive protein (hs-CRP); Diabetes; Trajectory
• ISSN: 1743-7075; 1743-7075
• DOI: 10.1186/s12986-020-00472-w

We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Included were 6439 adults (4111 men and 2249 women; aged 46.6 ± 11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (≥126 mg/dl) or Hb A1c (≥6.5%) during subsequent 3 years (2016-2018). Hs-CRP concentration during 2013-2015 was classified into 3 levels: low (< 1.0 mg/L), moderate (1.0-3.0 mg/L), and high (≥3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: "low-stable" (low in 2013 and maintained at low concentration in 2014 and 2015), "moderate-fluctuated" (moderate in 2013, then increased to high concentration in 2014, and decreased to low concentration in 2015), "high-decreased" (high in 2013 but decreased to moderate concentration in 2014 and 2015), and "moderate-increased (moderate in 2013 and increased to high concentration in 2014 and 2015)". We identified 235 incident diabetes during subsequent 3 years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderate-increased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, two single-measured hs-CRP concentration (in 2013 or in 2015) and the average of hs-CRP were associated with high risk of diabetes (P-trend< 0.01 for all). The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.