Migrasomes, new vescicles as Hansel and Gretel white pebbles?

• Published in: Biology direct Vol. 17; no. 1; p. 8
• Main Authors: Di Daniele, Arianna, Antonucci, Ylenia, Campello, Silvia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.04.2022; BioMed Central; BMC
• Subjects: Analysis; Biological properties; Biosynthesis; Cell interactions; Cell migration; Communication; Extracellular fluid; Extracellular vesicles; Extracellular Vesicles - metabolism; Genetic aspects; Heparan sulfate; Metabolism; Methods; Migrasome; Mitochondria; Molecular mechanics; Molecular modelling; Nanoparticles; Organelles; Plasma; Proteins; Proteins - metabolism; Review; Signal processing; Signal transduction; Signalling; Stem cells; Vesicles; Italy; Extracellular vesicles; Migrasome; Signalling; Cell migration; Communication
• ISSN: 1745-6150; 1745-6150
• DOI: 10.1186/s13062-022-00321-1

Migrasomes, released by migrating cells, belong to the heterogeneous world of extracellular vesicles (EVs). However, they can be distinguished from all other members of EVs by their size, biorigin and protein cargo. As far as we know, they can play important roles in various communication processes, by mediating the release of signals, such as mRNAs, proteins or damaged mitochondria. To extend and better understand the functional roles and importance of migrasomes, it is first essential to well understand the basic molecular mechanisms behind their formation and function. Herein, we endeavor to provide a brief and up-to-date description of migrasome biogenesis, release, characterization, biological properties and functional activities in cell-to-cell communication, and we will discuss and propose putative new functions for these vesicles.