Intricate crosstalk between MYB and noncoding RNAs in cancer

• Published in: Cancer cell international Vol. 21; no. 1; pp. 653 - 15
• Main Authors: Hu, Dingyu, Shao, Wenjun, Liu, Li, Wang, Yanyan, Yuan, Shunling, Liu, Zhaoping, Liu, Jing, Zhang, Ji
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.12.2021; BMC
• Subjects: Angiogenesis; Apoptosis; Binding sites; Breast cancer; Cancer; Colorectal cancer; Drug resistance; Feedback; Gene deletion; Gene expression; Kinases; Leukemia; LncRNAs; Medical prognosis; Metastases; Metastasis; MicroRNAs; miRNA; MiRNAs; MYB; Non-coding RNA; Noncoding RNAs; Pathogenesis; Proteins; Review; RNA processing; Senescence; Transcription factors; Tumorigenesis; Tumors; MiRNAs; Tumorigenesis; Noncoding RNAs; LncRNAs; MYB

MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to tumorigenesis, therefore, different tumor mechanisms produce similar MYB proteins. As MYB is...