Intricate crosstalk between MYB and noncoding RNAs in cancer

MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to tumorigenesis, therefore, different tumor mechanisms produce similar MYB proteins. As MYB is...

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Published inCancer cell international Vol. 21; no. 1; pp. 653 - 15
Main Authors Hu, Dingyu, Shao, Wenjun, Liu, Li, Wang, Yanyan, Yuan, Shunling, Liu, Zhaoping, Liu, Jing, Zhang, Ji
Format Journal Article
LanguageEnglish
Published England BioMed Central 07.12.2021
BMC
Subjects
Angiogenesis
Apoptosis
Binding sites
Breast cancer
Cancer
Colorectal cancer
Drug resistance
Feedback
Gene deletion
Gene expression
Kinases
Leukemia
LncRNAs
Medical prognosis
Metastases
Metastasis
MicroRNAs
miRNA
MiRNAs
MYB
Non-coding RNA
Noncoding RNAs
Pathogenesis
Proteins
Review
RNA processing
Senescence
Transcription factors
Tumorigenesis
Tumors
MiRNAs
Tumorigenesis
Noncoding RNAs
LncRNAs
MYB
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Summary:MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to tumorigenesis, therefore, different tumor mechanisms produce similar MYB proteins. As MYB is a transcription factor, priority has been given to identifying the genes that it regulates. All previous attention has been focused on protein-coding genes. However, an increasing number of studies have suggested that MYB can affect the complexity of cancer progression by regulating tumor-associated noncoding RNAs (ncRNAs), such as microRNAs, long-non-coding RNAs and circular RNAs. ncRNAs can regulate the expression of numerous downstream genes at the transcription, RNA processing and translation levels, thereby having various biological functions. Additionally, ncRNAs play important roles in regulating MYB expression. This review focuses on the intricate crosstalk between oncogenic MYB and ncRNAs, which play a pivotal role in tumorigenesis, including proliferation, apoptosis, angiogenesis, metastasis, senescence and drug resistance. In addition, we discuss therapeutic strategies for crosstalk between MYB and ncRNAs to prevent the occurrence and development of cancer.
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ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-021-02362-4