Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

• Published in: Health and quality of life outcomes Vol. 18; no. 1; pp. 307 - 12
• Main Authors: do Nascimento Santos Lima, Emanuelle, Ferreira, Isabela Borges, Lajolo, Paula Philbert, Paiva, Carlos Eduardo, de Paiva Maia, Yara Cristina, das Graças Pena, Geórgia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.09.2020; BioMed Central; BMC
• Subjects: Aged; Analysis; Cancer; Cancer patients; Cancer research; Cancer therapies; Care and treatment; Chemoradiotherapy; Chemoradiotherapy - adverse effects; Chemoradiotherapy - psychology; Chemotherapy; Cognitive ability; Exhausting; Female; Head; Head & neck cancer; Head and neck cancer; Head and neck neoplasms; Head and Neck Neoplasms - psychology; Head and Neck Neoplasms - therapy; Health-related quality of life; Humans; Larynx; Likert scale; Male; Metastasis; Middle Aged; Nausea; Oral cavity; Patients; Prospective Studies; Quality of Life; Questionnaires; Radiation therapy; Radiotherapy; Saliva; Self image; Standard deviation; Teeth; Treatment Outcome; Tumors; Vomiting; Health-related quality of life; Chemotherapy; Radiotherapy; Head and neck neoplasms
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-020-01543-5

Quality of life (QoL) is influenced in head and neck cancer (HNC) patients by a set of factors related to diagnosis, treatment and tumor impacts. The aim of this study was to evaluate the Quality of Life (QoL) changes in Head and Neck cancer (HNC) patients during treatment (radiotherapy and/or chemoradiotherapy). QoL was evaluated prospectively in 63 HNC patients during radiotherapy and/or chemoradiotherapy at three moments: before or at beginning (T0), in the middle (T1 ~ four weeks) and immediately at the end (T2 ~ eight weeks) of treatment. The differences between the scores at different time points was verified using Friedman's non-parametric test. Negative changes between time points were evaluated, with differences (delta) of ±10 points being considered to be clinically significant. The total mean age was 59.1 ± 9.5y, and 82.5% were male. The oral cavity and larynx were more frequent tumors. The functional score for 'role' was decreased at time points T1 and T2 as compared to T0, while an improvement in scores was observed for cognitive function. Several physical symptoms also worsened over time, such as: fatigue, nausea and vomiting, dry mouth and sticky saliva, swallowing and skin symptoms, senses and teeth problems. A high frequency of altered and clinically meaningful values were observed for most of domains, ranging from 6 to 74%. The QoL became worse at approximately one month after treatment beginning in HNC patients, and this remained until the end of therapy. Protocols directing to early nutritional counseling and management of symptoms of nutritional impact are important to improve clinical outcomes. This is part of preventive actions aiming to make the exhausting treatment process less traumatic and easier to complete.