A systematic review and meta-analysis on prevalence and distribution of Taenia and Echinococcus infections in Ethiopia

• Published in: Parasites & vectors Vol. 14; no. 1; p. 447
• Main Authors: Shumuye, Nigus Abebe, Ohiolei, John Asekhaen, Gebremedhin, Mebrahtu Berhe, Yan, Hong-Bin, Li, Li, Li, Wen-Hui, Zhang, Nian-Zhang, Fu, Bao-Quan, Jia, Wan-Zhong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.09.2021; BioMed Central; BMC
• Subjects: Abattoirs; Animals; Beef; Cattle; Cystic echinococcosis; Cysticercosis; Cysts; Datasets; Distribution; Domestication; Echinococcosis; Echinococcosis - epidemiology; Echinococcus; Endoparasites; Epidemiology; Ethiopia; Ethiopia - epidemiology; Goats - parasitology; Heterogeneity; Hosts; Humans; Infections; Interfaces; Livestock; Livestock - parasitology; Mathematical analysis; Meta-analysis; Parasites; Parasitic diseases; Parasitological research; Parasitoses; Pathogens; Prevalence; Review; Reviews; Risk factors; Search engines; Sheep; Statistical analysis; Statistical methods; Surveys; Systematic review; Taenia; Taenia - genetics; Taenia - isolation & purification; Taeniasis; Taeniasis - epidemiology; Tropical climate; Variability; Worms; Zoonoses; Ethiopia; Africa; Taeniasis; Cystic echinococcosis; Cysticercosis; Epidemiology; Ethiopia; Risk factors
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-021-04925-w

Tapeworm infections are among the tropical neglected parasitic diseases endemically occurring in Ethiopia. This systematic review and meta-analysis aims at estimating the pooled prevalence and distribution of Taenia and Echinococcus infections in humans and animals from reports from Ethiopia. The systematic search was conducted in four bibliographic databases (PubMed, Google Scholar, Africa Journal Online and Science Direct). Additional data were retrieved from grey literature. Studies that met the inclusion criteria were considered for the systematic review and meta-analysis. The meta-analysis was conducted using MetaXL add-in for Microsoft Excel. Heterogeneity and inconsistency were evaluated using Cochran's Q and I statistics, respectively. The study provides a country-based database of Taenia and Echinococcus infections consisting of 311 datasets from 201 publications which were mostly abattoir surveys; of these, 251 datasets were subjected to meta-analysis. Most of the studies were from Oromia (32.8%) followed by Amhara (22.9%) regional states. The pooled prevalence of cystic echinococcosis in intermediate and accidental hosts was calculated as 22% (95% CI 18-26%) and high study variability (Q = 24,420.65, I  = 100%, P = 0.000). Moreover, a pooled prevalence of Echinococcus infections in final hosts was calculated as 33% (95% CI 20-48%) and low study variability (Q = 17.24, I  = 65%, P = 0.001). Similarly, study subjects (human, cattle, sheep, goat and wolf) were infected by Taenia spp. with pooled prevalence of 3% (95% CI 2-4%) and moderate study variability (Q = 279.07, I  = 89, P = 0.000). Meanwhile, the pooled prevalence of Taenia hydatigena, T. ovis and T. multiceps infections in intermediate hosts were calculated as 38%, 14% and 5%, respectively. The random effect meta-analysis of bovine cysticercosis showed a pooled prevalence of 7% (95% CI 5-9%) and high study variability was of (Q = 4458.76; I  = 99%, P = 0.000). Significant differences in prevalence of Taenia and Echinococcus infections between study sites or different livestock origins have been reported. The study evidenced a comprehensive dataset on the prevalence and distribution of Taenia and Echinococcus infections at different interfaces by regions and hosts and hence can aid in the design of more effective control strategies.