Isabl Platform, a digital biobank for processing multimodal patient data

The widespread adoption of high throughput technologies has democratized data generation. However, data processing in accordance with best practices remains challenging and the data capital often becomes siloed. This presents an opportunity to consolidate data assets into digital biobanks-ecosystems...

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Bibliographic Details
Published inBMC bioinformatics Vol. 21; no. 1; p. 549
Main Authors Medina-Martínez, Juan S, Arango-Ossa, Juan E, Levine, Max F, Zhou, Yangyu, Gundem, Gunes, Kung, Andrew L, Papaemmanuil, Elli
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 30.11.2020
BioMed Central
BMC
Subjects
Analysis information management system
Applications programs
Artificial intelligence
Automation
Biological Specimen Banks
Catalysts
Data entry
Data processing
Databases, Factual
Evaluation
Genomics
Humans
Image processing
Information management
Internet
Methods
Multimodal user interfaces (Computers)
Next generation sequencing
Ontology
Relational data bases
Reproducibility of Results
Software
Software engineering
User-Computer Interface
United States
Image processing
Genomics
Data processing
Multimodal data
Analysis information management system
Next generation sequencing
Software engineering
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Summary:The widespread adoption of high throughput technologies has democratized data generation. However, data processing in accordance with best practices remains challenging and the data capital often becomes siloed. This presents an opportunity to consolidate data assets into digital biobanks-ecosystems of readily accessible, structured, and annotated datasets that can be dynamically queried and analysed. We present Isabl, a customizable plug-and-play platform for the processing of multimodal patient-centric data. Isabl's architecture consists of a relational database (Isabl DB), a command line client (Isabl CLI), a RESTful API (Isabl API) and a frontend web application (Isabl Web). Isabl supports automated deployment of user-validated pipelines across the entire data capital. A full audit trail is maintained to secure data provenance, governance and ensuring reproducibility of findings. As a digital biobank, Isabl supports continuous data utilization and automated meta analyses at scale, and serves as a catalyst for research innovation, new discoveries, and clinical translation.
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ISSN:1471-2105
1471-2105
DOI:10.1186/s12859-020-03879-7