Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis

• Published in: Canadian respiratory journal Vol. 2023; pp. 1 - 5
• Main Authors: Peng, You-Fan, Deng, Jun-Hua, Huang, Xiao-Ying, Zhang, Qing-Song
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 14.03.2023; John Wiley & Sons, Inc; Wiley
• Subjects: Antioxidants; Atazanavir; Bilirubin; Biomarkers; Cardiovascular disease; Chronic obstructive pulmonary disease; Coronary vessels; Correlation analysis; Development and progression; Diabetes; Efavirenz; Health aspects; Humans; Hypertension; Inflammation; Lungs; Medical research; Medicine, Experimental; Metabolic syndrome; Oxidative stress; Patient Acuity; Physiological aspects; Pneumoconiosis; Pneumoconiosis - diagnostic imaging; Proteins; Regression analysis; Retrospective Studies; Severity of Illness Index; Tuberculosis; Variables; Vein & artery diseases; Canada
• ISSN: 1198-2241; 1916-7245; 1916-7245
• DOI: 10.1155/2023/5642040

Aim. To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis. Methods. The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity. Results. Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage (p = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis (r = −0.320; p = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = −0.459; p = 0.005). Conclusions. Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.