Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

• Published in: BMC microbiology Vol. 20; no. 1; pp. 168 - 14
• Main Authors: Liu, Tong, Gu, Xiang, Li, Li-Xiang, Li, Ming, Li, Bing, Cui, Xiao, Zuo, Xiu-li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.06.2020; BioMed Central; BMC
• Subjects: Abundance; Adult; Analysis; Anxiety; Anxiety - metabolism; Anxiety - microbiology; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Case-Control Studies; Comorbidity; Correlation analysis; Depression; Depression (Mood disorder); Depression - metabolism; Depression - microbiology; Diarrhea; Diarrhea - metabolism; Diarrhea - microbiology; Diarrhea - psychology; DNA, Bacterial - genetics; DNA, Ribosomal - genetics; Fecal microflora; Feces - microbiology; Female; Gene sequencing; Glutarates - urine; Homoserine - analogs & derivatives; Homoserine - urine; Humans; Inositol; Intestinal microflora; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - microbiology; Irritable Bowel Syndrome - psychology; L-Serine; Male; Mental depression; Mental disorders; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Microbial community; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Middle Aged; Phylogeny; Population; Relative abundance; Resveratrol; RNA; RNA, Ribosomal, 16S - genetics; rRNA 16S; Sequence Analysis, DNA - methods; Urine - chemistry; Urine - microbiology; Xanthines - urine; Metabolomics; Depression; Anxiety; Microbial community; Irritable bowel syndrome

Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS. A total of 70 diarrhoea-predominant IBS (IBS-D) patients and 46 healthy cont...