Psychometric properties of the Chinese version of the modified polycystic ovary syndrome health-related quality-of-life questionnaire

• Published in: Health and quality of life outcomes Vol. 18; no. 1; pp. 131 - 11
• Main Authors: Luo, Yun-yun, Xu, Xiao-lin, Li, Xiao-bin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.05.2020; BioMed Central; BMC
• Subjects: Acne; Adult; Analysis; Blood diseases; Case-Control Studies; China; Consistency; Correlation coefficient; Correlation coefficients; Factor analysis; Female; Hospitals; Humans; Infertility; Measuring instruments; Medical research; Menstruation; Mental depression; Polycystic ovary syndrome; Polycystic Ovary Syndrome - psychology; Population; Principal components analysis; Professionals; Psychometrics - instrumentation; Quality; Quality of Life; Quantitative psychology; Questionnaires; Reliability analysis; Reproducibility of Results; Researchers; Statistical analysis; Surveys; Surveys and Questionnaires - standards; Validation studies; Validation study; Validity; Womens health; Young Adult; China; Polycystic ovary syndrome; Quality of life; Validation study
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-020-01380-6

The modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30-item instrument measuring quality-of-life in English-speaking patients with polycystic ovary syndrome (PCOS). We aimed to: 1) cross-culturally adapt the MPCOSQ into Chinese, and 2) assess the validity and reliability of the Chinese version of the MPCOSQ (Chi-MPCOSQ). The MPCOSQ was translated using the forward-backward method, and its validity and reliability were assessed among 283 Chinese patients with PCOS. Internal consistency reliability and test-retest reliability were assessed by Cronbach's α and intra-correlation coefficient (ICC), respectively. Construct validity was tested through exploratory factor analysis and confirmatory factor analysis. Discriminant validity was assessed by Mann-Whitney U test to compare the scores on the Chi-MPCOSQ between 283 women with PCOS and 93 women without PCOS. Exploratory factor analysis generated a 7-factor structure of the 30-item version of the Chi-MPCOSQ, which accounted for 77% of the overall variance. The Chi-MPCOSQ had high internal consistency (Cronbach's α = 0.88) and good test-retest reliability (ICC = 0.89). Compared to PCOS patients, women without PCOS had consistently lower scores for every dimension of the Chi-MPCOSQ, demonstrating its good discriminant validity. The Chi-MPCOSQ is a valid and reliable instrument for measuring quality-of-life among Chinese women with PCOS.