Case–control study on TP73 rs1801173 C > T gene polymorphism and susceptibility to gastric cancer in a Chinese Han population

This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele...

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Published inBMC medical genomics Vol. 15; no. 1; pp. 14 - 6
Main Authors Pan, Huiwen, Gu, Xuyu, Wang, Xiaoyan, Gao, Zhenjun, Ding, Guowen, Zou, Chen, Fan, Yu
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.01.2022
BioMed Central
BMC
Subjects
Age
Alcohol
Analysis
Cancer
Care and treatment
Case-Control Studies
Cervical cancer
China - epidemiology
Diagnosis
Disease susceptibility
DNA polymerase
Gastric cancer
Gene Frequency
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotyping
Humans
Mutation
Pathogenesis
Patients
Polymorphism
Polymorphism, Single Nucleotide
Population
Population studies
Regression analysis
Risk factors
rs1801173
Sample size
Single nucleotide polymorphism (SNP)
Smoking
Software
Stomach cancer
Stomach Neoplasms - genetics
Testing
TP73 gene
China
rs1801173
Gastric cancer
Single nucleotide polymorphism (SNP)
TP73 gene
Online AccessGet full text

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Abstract This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
AbstractList This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer.BACKGROUNDThis study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer.We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method.METHODSWe conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method.The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763).RESULTSThe findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763).Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.CONCLUSIONSmoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
Background This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Methods We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. Results The findings showed that the control group had consistent genotype frequency distribution and presented Hardy–Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Conclusion Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
Background This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Methods We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. Results The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Conclusion Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer. Keywords: TP73 gene, Gastric cancer, Single nucleotide polymorphism (SNP), rs1801173
Abstract Background This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Methods We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. Results The findings showed that the control group had consistent genotype frequency distribution and presented Hardy–Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Conclusion Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
ArticleNumber 14
Audience Academic
Author Zou, Chen
Gu, Xuyu
Pan, Huiwen
Gao, Zhenjun
Wang, Xiaoyan
Ding, Guowen
Fan, Yu
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Issue 1
Keywords rs1801173
Gastric cancer
Single nucleotide polymorphism (SNP)
TP73 gene
Language English
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Snippet This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary...
This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary...
Background This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Methods We conducted a case-controlled study...
This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer.BACKGROUNDThis study investigated the role of TP73 gene...
Abstract Background This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Methods We conducted a case-controlled...
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StartPage 14
SubjectTerms Age
Alcohol
Analysis
Cancer
Care and treatment
Case-Control Studies
Cervical cancer
China - epidemiology
Diagnosis
Disease susceptibility
DNA polymerase
Gastric cancer
Gene Frequency
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotyping
Humans
Mutation
Pathogenesis
Patients
Polymorphism
Polymorphism, Single Nucleotide
Population
Population studies
Regression analysis
Risk factors
rs1801173
Sample size
Single nucleotide polymorphism (SNP)
Smoking
Software
Stomach cancer
Stomach Neoplasms - genetics
Testing
TP73 gene
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Title Case–control study on TP73 rs1801173 C > T gene polymorphism and susceptibility to gastric cancer in a Chinese Han population
URI https://www.ncbi.nlm.nih.gov/pubmed/35073920
https://www.proquest.com/docview/2630460344
https://www.proquest.com/docview/2622660550
https://pubmed.ncbi.nlm.nih.gov/PMC8785439
https://doaj.org/article/a6b44604b1134d8982c182aa51c64305
Volume 15
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