Case–control study on TP73 rs1801173 C > T gene polymorphism and susceptibility to gastric cancer in a Chinese Han population

• Published in: BMC medical genomics Vol. 15; no. 1; pp. 14 - 6
• Main Authors: Pan, Huiwen, Gu, Xuyu, Wang, Xiaoyan, Gao, Zhenjun, Ding, Guowen, Zou, Chen, Fan, Yu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.01.2022; BioMed Central; BMC
• Subjects: Age; Alcohol; Analysis; Cancer; Care and treatment; Case-Control Studies; Cervical cancer; China - epidemiology; Diagnosis; Disease susceptibility; DNA polymerase; Gastric cancer; Gene Frequency; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Genotyping; Humans; Mutation; Pathogenesis; Patients; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Regression analysis; Risk factors; rs1801173; Sample size; Single nucleotide polymorphism (SNP); Smoking; Software; Stomach cancer; Stomach Neoplasms - genetics; Testing; TP73 gene; China; rs1801173; Gastric cancer; Single nucleotide polymorphism (SNP); TP73 gene
• ISSN: 1755-8794; 1755-8794
• DOI: 10.1186/s12920-021-01151-2

This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method. The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763). Smoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.