Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

• Published in: Molecular and Cellular Biology Vol. 28; no. 10; pp. 3258 - 3272
• Main Authors: Bayascas, Jose R., Wullschleger, Stephan, Sakamoto, Kei, García-Martínez, Juan M., Clacher, Carol, Komander, David, van Aalten, Daan M. F., Boini, Krishna M., Lang, Florian, Lipina, Christopher, Logie, Lisa, Sutherland, Calum, Chudek, John A., van Diepen, Janna A., Voshol, Peter J., Lucocq, John M., Alessi, Dario R.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.05.2008; Taylor & Francis; American Society for Microbiology (ASM)
• Subjects: Amino Acid Substitution; Animals; Body Size - genetics; Body Size - physiology; Female; Insulin Resistance - genetics; Insulin Resistance - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenotype; Prediabetic State - genetics; Prediabetic State - metabolism; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases - chemistry; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins c-akt - antagonists & inhibitors
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.02032-07

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