Intensive care-related loss of quality of life and autonomy at 6 months post-discharge: Does COVID-19 really make things worse?

• Published in: Critical care (London, England) Vol. 26; no. 1; p. 94
• Main Authors: Thiolliere, Fabrice, Falandry, Claire, Allaouchiche, Bernard, Geoffray, Victor, Bitker, Laurent, Reignier, Jean, Abraham, Paul, Malaquin, Stephanie, Balança, Baptiste, Boyer, Hélène, Seguin, Philippe, Guichon, Céline, Simon, Marie, Friggeri, Arnaud, Vacheron, Charles-Hervé
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.04.2022; BioMed Central; BMC
• Subjects: Activities of daily living; Aftercare; Aged; Autonomy; Complications and side effects; Coronaviruses; COVID-19; Critical Care; Critical care medicine; Health aspects; Humans; Intensive care; Intensive Care Units; Life Sciences; Outcome Assessment, Health Care; Patient Discharge; Patient outcomes; Prospective Studies; Quality of Life; France; COVID-19; Autonomy; Quality of life
• ISSN: 1364-8535; 1466-609X; 1364-8535; 1366-609X
• DOI: 10.1186/s13054-022-03958-6

To compare old patients hospitalized in ICU for respiratory distress due to COVID-19 with old patients hospitalized in ICU for a non-COVID-19-related reason in terms of autonomy and quality of life. Comparison of two prospective multi-centric studies. This study was based on two prospective multi-centric studies, the Senior-COVID-Rea cohort (COVID-19-diagnosed ICU-admitted patients aged over 60) and the FRAGIREA cohort (ICU-admitted patients aged over 70). We included herein the patients from both cohorts who had been evaluated at day 180 after admission (ADL score and quality of life). None. A total of 93 COVID-19 patients and 185 control-ICU patients were included. Both groups were not balanced on age, body mass index, mechanical ventilation, length of ICU stay, and ADL and SAPS II scores. We modeled with ordered logistic regression the influence of COVID-19 on the quality of life and the ADL score. After adjustment on these factors, we observed COVID-19 patients were less likely to have a loss of usual activities (aOR [95% CI] 0.47 [0.23; 0.94]), a loss of mobility (aOR [95% CI] 0.30 [0.14; 0.63]), and a loss of ADL score (aOR [95% CI] 0.30 [0.14; 0.63]). On day 180, 52 (56%) COVID-19 patients presented signs of dyspnea, 37 (40%) still used analgesics, 17 (18%) used anxiolytics, and 14 (13%) used antidepressant. COVID-19-related ICU stay was not associated with a lower quality of life or lower autonomy compared to non-COVID-19-related ICU stay.