Transcriptional regulation of lipid homeostasis in mycobacteria

• Published in: Molecular microbiology Vol. 78; no. 1; pp. 64 - 77
• Main Authors: Salzman, V, Mondino, S, Sala, C, Cole, S.T, Gago, G, Gramajo, H
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.10.2010; Blackwell Publishing Ltd; Blackwell
• Subjects: Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Binding Sites; Biochemistry; Biological and medical sciences; Enzymes; Fatty Acid Synthase, Type II - genetics; Fatty Acid Synthase, Type II - metabolism; Fatty acids; Fatty Acids - biosynthesis; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation, Bacterial; Genes, Regulator; Homeostasis; Lipid Metabolism; Microbiology; Miscellaneous; Mutation; Mycobacterium smegmatis; Mycobacterium smegmatis - enzymology; Mycobacterium smegmatis - genetics; Mycobacterium tuberculosis; Operon; Promoter Regions, Genetic; Mycobacterium; Regulation(control); Transcription; Mycobacteriales; Mycobacteriaceae; Homeostasis; Bacteria; Lipids; Actinomycetes

Mycolic acids are major components of the cell envelope of mycobacteria, such as Mycobacterium tuberculosis, and play an important role in its architecture, impermeability and interaction with the environment. Synthesis of mycolic acids is carried out by two types of fatty acid synthases (FAS) worki...