脑出血与同型半胱氨酸的临床相关性分析

目的探讨血清同型半胱氨酸及凝血指标与脑出血的相关性及其临床意义。方法选择2010年1月-2014年12月在我院经头颅计算机断层扫描（computed tomography,CT）证实的脑出血的住院患者146例为脑出血组,同期在我院进行体检的健康人员158例为对照组,将两组患者按年龄分为青年组、中年组、年轻老年组、老老年组4个亚组。分析脑出血组同型半胱氨酸（homocysteine,Hcy）的异常检出率,并对Hcy与年龄进行直线相关性分析。比较以上各亚组间血清Hcy值、D-二聚体、凝血酶原时间、凝血酶原时间活动度（prothrombin time activity,PTA）、国际标准化比值、活化...

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Bibliographic Details
Published in中国卒中杂志 Vol. 12; no. 8; pp. 691 - 695
Main Author 张英 崇丽宁 李继梅
Format Journal Article
LanguageChinese
Published 100050 北京 首都医科大学附属北京友谊医院神经内科 2017
邯郸市中心医院神经内科%100050,北京 首都医科大学附属北京友谊医院神经内科
Subjects
凝血功能
同型半胱氨酸
脑出血
凝血功能
脑出血
Homocysteine
同型半胱氨酸
Cerebral hemorrhage
Blood coagulation index
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Summary:目的探讨血清同型半胱氨酸及凝血指标与脑出血的相关性及其临床意义。方法选择2010年1月-2014年12月在我院经头颅计算机断层扫描（computed tomography,CT）证实的脑出血的住院患者146例为脑出血组,同期在我院进行体检的健康人员158例为对照组,将两组患者按年龄分为青年组、中年组、年轻老年组、老老年组4个亚组。分析脑出血组同型半胱氨酸（homocysteine,Hcy）的异常检出率,并对Hcy与年龄进行直线相关性分析。比较以上各亚组间血清Hcy值、D-二聚体、凝血酶原时间、凝血酶原时间活动度（prothrombin time activity,PTA）、国际标准化比值、活化部分凝血酶原时间、纤维蛋白原（fibrinogen,Fbg）水平并进行Logistic回归分析。结果 （1）脑出血组血清Hcy水平增高104例（71.2%）,男性患者增高明显（83.3%）,与对照组比较差异具有显著性。（2）脑出血组Hcy、Fbg水平比对照组各亚组均显著增高;PTA水平在中年组以上增高,与同龄对照组比较差异具有显著性;D-二聚体水平在老老年组与同龄对照组比较显著增高。（3）Logistic回归分析结果显示,Hcy、D-二聚体和Fbg为脑出血的独立危险因素。结论 Hcy是脑出血的危险因素,因此,在脑出血的预防和治疗策略中亦应重视对高同型半胱氨酸血症的干预。
Bibliography:ZHANG Ying, CHONG Li-Ning, LI Ji-Mei（ Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China）
11-5434/R
Homocysteine; Cerebral hemorrhage; Blood coagulation index
Objective To explore the clinic significance and the correlation between the serum homocystein（Hcy） and blood coagulation index in cerebral hemorrhage.Methods A total of 146 patients with cerebral hemorrhage receiving treatment in the hospital from 2010 to 2014 were selected as the study subjects and contemporaneous 158 healthy individuals of physical examination were taken as the control group. The patients in two groups were divided into the youth group, middle age group, elderly age group and the longevity group by age. The Hcy anomaly detection rate of cerebral hemorrhage group were analyzed, and the linear correlation analysis between homocysteine and age was also made. The values of serum Hcy, D-Dimer, prothrombin time（PT）, prothrombin time activity（PTA）, international standardization ratio（INR）, a
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2017.08.007