甲氧氯普胺兴奋试验对高泌乳素血症的病因诊断价值及其影响因素

目的：探讨甲氧氯普胺（胃复安）兴奋试验对高泌乳素血症的病因诊断价值,并分析可能的影响因素。方法：收集2013年11月至2015年3月在复旦大学附属华山医院内分泌科住院的53例临床确诊的高泌乳素血症患者。所有患者入院后均行胃复安兴奋试验和其他相关实验室检查,分析相关影响因素。结果：53例高泌乳素血症患者包括泌乳素瘤37例,其他病因16例。胃复安兴奋试验鉴别泌乳素瘤的灵敏度为81.08%,特异度为68.75%,准确度为77.36%;一致性检验Kappa值=0.481（P〈0.05）。多元Logistic回归分析提示,胃复安兴奋试验兴奋与否与0min泌乳素水平独立相关（OR=1.035,95%CI1...

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Published in中国临床医学 Vol. 24; no. 2; pp. 191 - 193
Main Author 伊娜 赵文婷 何敏 杨叶虹 张朝云 刘红 叶红英 李益明 鹿斌
Format Journal Article
LanguageChinese
Published 复旦大学附属华山医院内分泌科,上海,200040 2017
Subjects
泌乳素瘤
胃复安兴奋试验
高泌乳素血症
泌乳素瘤
高泌乳素血症
hyperprolactinemia
prolactinoma
metoclopramidstimulation test
胃复安兴奋试验
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Summary:目的：探讨甲氧氯普胺（胃复安）兴奋试验对高泌乳素血症的病因诊断价值,并分析可能的影响因素。方法：收集2013年11月至2015年3月在复旦大学附属华山医院内分泌科住院的53例临床确诊的高泌乳素血症患者。所有患者入院后均行胃复安兴奋试验和其他相关实验室检查,分析相关影响因素。结果：53例高泌乳素血症患者包括泌乳素瘤37例,其他病因16例。胃复安兴奋试验鉴别泌乳素瘤的灵敏度为81.08%,特异度为68.75%,准确度为77.36%;一致性检验Kappa值=0.481（P〈0.05）。多元Logistic回归分析提示,胃复安兴奋试验兴奋与否与0min泌乳素水平独立相关（OR=1.035,95%CI1.011~1.059,P〈0.001）。结论：胃复安兴奋试验对高泌乳素血症病因诊断具有较好的价值,但应考虑试验前泌乳素基线水平的影响。
Bibliography:31-1794/R
metoclopramide stimulation test; hyperprolactinemia; prolactinoma
YI Na,ZHAO Wen-ting,HE Min, YANG Ye-hong,ZHANG Zhao-yun,LIU Hong, YE Hong-ying,LI Yi-ming,LU Bin（ Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200040,China）
Objective To investigate the value of metoclopramide stimulation test in etiological diagnosis of hyperprolactinemia,and to analyze its possible influencing factors. Methods： Fifty-three patients with hyperprolactinemia treated in Department of Endocrinology of Huashan Hospital from November 2013 to March 2015 were enrolled. The metoclopramide stimulation test and the other related laboratory tests were performed to analyze the factors affecting test results. Results： In all the 53 hyperprolactinemia patients,37 patients were diagnosed with prolactinoma. The diagnostic sensitivity of the metoclopramide stimulation test for hyperprolactinemia was 81. 08%, the specificity was 68 . 75 % ,and the accuracy was 77. 36%. The consistency test showed a Kappa value
ISSN:1008-6358
DOI:10.12025/j.issn.1008-6358.2017.20161216