取代咪唑并[1,2-a]吡啶-2-羧酸的合成与表征
通过比较文献报道的方法,解决其中存在的各种限制条件,对原有取代咪唑并[1,2-a]吡啶-2-羧酸的合成方法进行改进,建立产品合成的新方法,并运用核磁、红外、质谱等手段对其结构进行表征。同时进一步通过改变反应条件、合成路线等方法,使各个种类中间体的制备工艺均具有普遍性,从而具有实际应用价值,为其在药物合成领域的应用提供可行的途径。...
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| Published in | 辽东学院学报（自然科学版） Vol. 25; no. 1; pp. 24 - 27 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
辽东学院 化学工程学院,辽宁,丹东 118003
2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-4939 |
| DOI | 10.14168/j.issn.1673-4939.2018.01.05 |
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| Abstract | 通过比较文献报道的方法,解决其中存在的各种限制条件,对原有取代咪唑并[1,2-a]吡啶-2-羧酸的合成方法进行改进,建立产品合成的新方法,并运用核磁、红外、质谱等手段对其结构进行表征。同时进一步通过改变反应条件、合成路线等方法,使各个种类中间体的制备工艺均具有普遍性,从而具有实际应用价值,为其在药物合成领域的应用提供可行的途径。 |
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| AbstractList | O626.32; 通过比较文献报道的方法,解决其中存在的各种限制条件,对原有取代咪唑并[1,2-a]吡啶-2-羧酸的合成方法进行改进,建立产品合成的新方法,并运用核磁、红外、质谱等手段对其结构进行表征.同时进一步通过改变反应条件、合成路线等方法,使各个种类中间体的制备工艺均具有普遍性,从而具有实际应用价值,为其在药物合成领域的应用提供可行的途径. 通过比较文献报道的方法,解决其中存在的各种限制条件,对原有取代咪唑并[1,2-a]吡啶-2-羧酸的合成方法进行改进,建立产品合成的新方法,并运用核磁、红外、质谱等手段对其结构进行表征。同时进一步通过改变反应条件、合成路线等方法,使各个种类中间体的制备工艺均具有普遍性,从而具有实际应用价值,为其在药物合成领域的应用提供可行的途径。 |
| Author | 张慧东;陈秋宇;张霞;高铭远 |
| AuthorAffiliation | 辽东学院化学工程学院,辽宁丹东118003 |
| AuthorAffiliation_xml | – name: 辽东学院 化学工程学院,辽宁,丹东 118003 |
| Author_FL | GAO Ming-yuan CHEN Qiu-yu ZHANG Hui-dong ZHANG Xia |
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| Author_xml | – sequence: 1 fullname: 张慧东;陈秋宇;张霞;高铭远 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitleAlternate | Synthesis and characterization of imidazole and [1,2-a] pyridine-2-carboxylic acid |
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| EndPage | 27 |
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| Keywords | 表征 5-甲基-咪唑并[1,2-a]吡啶-2-羧酸 合成 6-溴-咪唑并[1,2-a]吡啶-2-羧酸 6-硝基-咪唑并[1,2-a]吡啶-2-羧酸 |
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| Notes | The synthesis of imidazole and [1,2-a] pyridine-2-carboxylic acid was improved.The structure of the obtained product was characterized with NMR,IR and MS.By changing the reaction conditions and synthetic route,the preparation technology of the intermediates is universal,thus making the synthesis of the product to be feasible in the field of medicine.. 5-methyl -im idazole and [1 ,2-a] pyridine - 2-carbox ylic acid; 6-brom o-im idazole and [1 ,2-a]pyridine 2-carbox yl ic acid; 6- ni tromim idazole and [1 ,2-a] pyridine - 2-carbox ylic acid; synthesis;characterization ZHANG Hui-dong,CHEN Qiu-yu,ZHANG Xia,GAO Ming-yuan（ School of Chemical Engineering,Eastern Liaoning University,Dandong 118003,China ） 21-1533/N |
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| SubjectTerms | 5-甲基-咪唑并[1,2-a]吡啶-2-羧酸 6-溴-咪唑并[1,2-a]吡啶-2-羧酸 6-硝基-咪唑并[1,2-a]吡啶-2-羧酸 合成 表征 |
| Title | 取代咪唑并[1,2-a]吡啶-2-羧酸的合成与表征 |
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