参芪多糖泡腾片免疫调节作用的药理研究

目的 考察参芪多糖泡腾片对小鼠和大鼠的免疫调节作用。方法 通过碳粒廓清试验及2,4-二硝基氟苯(DNFB)诱导小鼠迟发型变态反应,通过测定小鼠右耳肿胀度和肝、脾、胸腺指数,考察参芪多糖泡腾片对小鼠的免疫调节作用;通过测定注射用环磷酰胺(CTX)致免疫低下大鼠脾指数、胸腺指数,肿瘤坏死因子-α(TNF-α)和白介素-2(IL-2)水平等的变化,考察参芪多糖泡腾片对大鼠的免疫调节作用。结果 参芪多糖泡腾片能够升高小鼠肝指数、脾指数、廓清指数K值及吞噬指数α值;增强DNFB诱导的小鼠迟发型变态反应;并升高CTX所致免疫低下大鼠脾指数和TNF-α、IL-2水平。结论 参芪多糖泡腾片具有增强小鼠特异性免...

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Bibliographic Details
Published in现代医药卫生 Vol. 32; no. 1; pp. 51 - 53
Main Author 任娟 顾燕
Format Journal Article
LanguageChinese
Published 江苏省中医院,南京,210029%江苏睿博医药有限公司,江苏南京,211112 2016
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Summary:目的 考察参芪多糖泡腾片对小鼠和大鼠的免疫调节作用。方法 通过碳粒廓清试验及2,4-二硝基氟苯(DNFB)诱导小鼠迟发型变态反应,通过测定小鼠右耳肿胀度和肝、脾、胸腺指数,考察参芪多糖泡腾片对小鼠的免疫调节作用;通过测定注射用环磷酰胺(CTX)致免疫低下大鼠脾指数、胸腺指数,肿瘤坏死因子-α(TNF-α)和白介素-2(IL-2)水平等的变化,考察参芪多糖泡腾片对大鼠的免疫调节作用。结果 参芪多糖泡腾片能够升高小鼠肝指数、脾指数、廓清指数K值及吞噬指数α值;增强DNFB诱导的小鼠迟发型变态反应;并升高CTX所致免疫低下大鼠脾指数和TNF-α、IL-2水平。结论 参芪多糖泡腾片具有增强小鼠特异性免疫和非特异性免疫功能、提高大鼠免疫力的作用。
Bibliography:Polysaccharides; Tablets; Codonopsis pilosula/pharmacology; Astragalus membranaceus/pharmacology; Immunocompetence; Hypersensitivity; Delayed; Carbon clearance test
Ren Juan,Gu Yan(1. Jiangsu Provincial Hospital of Traditional Chinese Medicine ,Nanjing,Jiangsu 210029, China;2. Jiangsu Ruibo Pharmaceutical Co. ,Ltd. , N anj ing , Jiangs u 211112, China)
Objective To investigate the immunoregulation effects of Shenqi Polysaccharide Effervescent Tablets in mice and rats. Methods The carbon particle clearance test and 2,4-dinitrofluorobenzene(DNFB) were used to induce the mice delayed type hypersensitivity reaction,the changes of the spleen index,thymus index,TNF-α and IL-2 in immunosuppressed rats caused by cyclophosphamide(CTX) were detected for investigating the immunoregulation effects of Shenqi Polysaccharide Effer-vescent Tablets in rats. Results Shenqi Polysaccharide Effervescent Tablets could increase the liver index,spleen index,clearance index K value and phagocytic index α value;and enhanced the spleen i
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2016.01.017