肺癌患者的躯体化症状及与焦虑抑郁的相关性研究
背景与目的肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15,PHQ-15）中文版进行躯体症状统计,用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale,HAMA）和汉密尔顿抑郁他评量表（H...
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| Published in | 中国肺癌杂志 Vol. 20; no. 7; pp. 473 - 478 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国医科大学附属盛京医院第四肿瘤科, 沈阳,110004
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
| DOI | 10.3779/j.issn.1009-3419.2017.07.06 |
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| Abstract | 背景与目的肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15,PHQ-15）中文版进行躯体症状统计,用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale,HAMA）和汉密尔顿抑郁他评量表（Hamilton Depression Scale,HAMD）评定焦虑和抑郁状态。计算焦虑或抑郁检出率及不同程度躯体化症状人数,分析躯体化症状与焦虑、抑郁的相关性,统计不同躯体化症状发生频率的分布情况。结果 50例具有躯体化症状的肺癌患者中,存在焦虑抑郁情绪的患者有43例,仅焦虑、仅抑郁及焦虑合并抑郁的患病率分别为10%、10%、66%,其中躯体化症状程度越高,焦虑合并抑郁的检出率越高。躯体化症状与焦虑、抑郁的相关分析显示,PHQ-15总分、PHQ-15阳性症状数目与HAMA得分（r=0.752,P〈0.001;r=0.710,P〈0.001）、HAMD得分（r=0.648,P〈0.001;r=0.618,P〈0.001）呈显著正相关。具有躯体化症状的肺癌患者临床症状出现频率由高到低依次是疲劳（96%）、虚弱感（88%）、睡眠障碍（84%）、头晕（82%）、肢体或关节疼痛（80%）等;不同性别肺癌患者之间的躯体化症状比较差异无统计学意义（P〉0.05）。结论具有躯体化症状的肺癌患者焦虑、抑郁常见,躯体化症状与焦虑、抑郁密切相关,此类患者最常见的临床症状为非特异性全身不适症状。 |
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| AbstractList | 背景与目的肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15,PHQ-15）中文版进行躯体症状统计,用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale,HAMA）和汉密尔顿抑郁他评量表（Hamilton Depression Scale,HAMD）评定焦虑和抑郁状态。计算焦虑或抑郁检出率及不同程度躯体化症状人数,分析躯体化症状与焦虑、抑郁的相关性,统计不同躯体化症状发生频率的分布情况。结果 50例具有躯体化症状的肺癌患者中,存在焦虑抑郁情绪的患者有43例,仅焦虑、仅抑郁及焦虑合并抑郁的患病率分别为10%、10%、66%,其中躯体化症状程度越高,焦虑合并抑郁的检出率越高。躯体化症状与焦虑、抑郁的相关分析显示,PHQ-15总分、PHQ-15阳性症状数目与HAMA得分（r=0.752,P〈0.001;r=0.710,P〈0.001）、HAMD得分（r=0.648,P〈0.001;r=0.618,P〈0.001）呈显著正相关。具有躯体化症状的肺癌患者临床症状出现频率由高到低依次是疲劳（96%）、虚弱感（88%）、睡眠障碍（84%）、头晕（82%）、肢体或关节疼痛（80%）等;不同性别肺癌患者之间的躯体化症状比较差异无统计学意义（P〉0.05）。结论具有躯体化症状的肺癌患者焦虑、抑郁常见,躯体化症状与焦虑、抑郁密切相关,此类患者最常见的临床症状为非特异性全身不适症状。 背景与目的 肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位.肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状.目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析.方法 对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表(Patient Health Questionnaire-15,PHQ-15)中文版进行躯体症状统计,用汉密尔顿焦虑他评量表(Hamilton Anxiety Scale,HAMA)和汉密尔顿抑郁他评量表(Hamilton Depres-sion Scale,HAMD)评定焦虑和抑郁状态.计算焦虑或抑郁检出率及不同程度躯体化症状人数,分析躯体化症状与焦虑、抑郁的相关性,统计不同躯体化症状发生频率的分布情况.结果 50例具有躯体化症状的肺癌患者中,存在焦虑抑郁情绪的患者有43例,仅焦虑、仅抑郁及焦虑合并抑郁的患病率分别为10%、10%、66%,其中躯体化症状程度越高,焦虑合并抑郁的检出率越高.躯体化症状与焦虑、抑郁的相关分析显示,PHQ-15总分、PHQ-15阳性症状数目与HAMA得分(r=0.752,P<0.001;r=0.710,P<0.001)、HAMD得分(r=0.648,P<0.001;r=0.618,P<0.001)呈显著正相关.具有躯体化症状的肺癌患者临床症状出现频率由高到低依次是疲劳(96%)、虚弱感(88%)、睡眠障碍(84%)、头晕(82%)、肢体或关节疼痛(80%)等;不同性别肺癌患者之间的躯体化症状比较差异无统计学意义(P>0.05).结论 具有躯体化症状的肺癌患者焦虑、抑郁常见,躯体化症状与焦虑、抑郁密切相关,此类患者最常见的临床症状为非特异性全身不适症状. |
| Abstract_FL | Background and objective Lung cancer is a serious threat to human health and its morbidity and mortality in recent years has always been ranked first in the country. Lung cancer patients are often associated with anxiety,depression and other emotional problems, and anxiety, depression and other emotional problems will further lead to a series of somatic symptoms. At present, we lack the clinical understanding of somatization symptoms in patients with lung cancer and related clinical studies are not too much. This research is to study the features of clinical manifestation of lung cancer patients with somatization symptoms and correlative analysis between anxiety, depression and somatization symptoms in medical on-cology department of general hospital. Methods Lung cancer patients who met somatization symptoms diagnostic standard were assessed with the self-constructed somatic symptoms investigation questionnaire, the Chinese version of the Patient Health Questionnaire-15 (PHQ-15) and anxiety and depression were recorded by the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD). The detection rate of the anxiety, depression and the number of patients with different severity somatization symptoms were calculated, the relationship between the PHQ-15 scores and anxiety and/or depression and the distribution of the different frequency somatization symptoms were analyzed. Results There were 43 patients with anxiety and/or depression in the 50 lung cancer patients with somatization symptoms. Prevalence rates of anxiety, depression and anxiety combined with depression were 10%, 10% and 66% respectively. The more severity the somatization symptoms are, the higher detection rates of anxiety combined with depression are. Significant positive correlations were observed between PHQ-15 scores, PHQ-15 positive symptom numbers and HAMA scores (r=0.752, P<0.001; r=0.710, P<0.001), HAMD scores (r=0.648, P<0.001; r=0.618, P<0.001). The most common somatization symptoms were fatigue (96%), weakness (88%),sleep disturbance (84%), dizziness (82%), and pain in extremities (80%). There was no significant statistical difference in somatization symptoms between lung cancer patients with different gender (P>0.05). Conclusion Symptoms of anxiety or depression were very common in lung cancer patients with somatization symptoms and there was a close relationship between anxiety, depression, and somatization symptoms. The most common symptoms of these patients were nonspecific generalized symptoms. |
| Author | 张心尧 张晓晔 |
| AuthorAffiliation | 中国医科大学附属盛京医院第四肿瘤科,沈阳110004 |
| AuthorAffiliation_xml | – name: 中国医科大学附属盛京医院第四肿瘤科, 沈阳,110004 |
| Author_FL | Xiaoye ZHANG Xinyao ZHANG |
| Author_FL_xml | – sequence: 1 fullname: Xinyao ZHANG – sequence: 2 fullname: Xiaoye ZHANG |
| Author_xml | – sequence: 1 fullname: 张心尧 张晓晔 |
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| Notes | Lung neoplasms;Somatization symptoms;Anxiety and depression Background and objective Lung cancer is a serious threat to human health and its morbidity and mortality in recent years has always been ranked first in the country. Lung cancer patients are often associated with anxiety,depression and other emotional problems, and anxiety, depression and other emotional problems will further lead to a series of somatic symptoms. At present, we lack the clinical understanding of somatization symptoms in patients with lung cancer and related clinical studies are not too much. This research is to study the features of clinical manifestation of lung cancer patients with somatization symptoms and correlative analysis between anxiety, depression and somatization symptoms in medical on-cology department of general hospital. Methods Lung cancer patients who met somatization symptoms diagnostic standard were assessed with the self-constructed somatic symptoms investigation questionnaire, the Chinese version of the Patient Hea |
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| PublicationTitle | 中国肺癌杂志 |
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| Title | 肺癌患者的躯体化症状及与焦虑抑郁的相关性研究 |
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