肺癌患者的躯体化症状及与焦虑抑郁的相关性研究

背景与目的肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15,PHQ-15）中文版进行躯体症状统计,用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale,HAMA）和汉密尔顿抑郁他评量表（H...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 20; no. 7; pp. 473 - 478
Main Author 张心尧 张晓晔
Format Journal Article
LanguageChinese
Published 中国医科大学附属盛京医院第四肿瘤科, 沈阳,110004 2017
Subjects
焦虑抑郁
肺肿瘤
躯体化症状
躯体化症状
焦虑抑郁
Somatization symptoms
Anxiety and depression
肺肿瘤
Lung neoplasms
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Summary:背景与目的肺癌是一种严重威胁人类健康的恶性肿瘤,其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题,而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前,临床上对于肺癌患者的躯体化症状认识不足,相关的临床研究较少,本研究以肿瘤内科患者为研究对象,探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法对符合躯体化症状诊断标准的肺癌患者,用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15,PHQ-15）中文版进行躯体症状统计,用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale,HAMA）和汉密尔顿抑郁他评量表（Hamilton Depression Scale,HAMD）评定焦虑和抑郁状态。计算焦虑或抑郁检出率及不同程度躯体化症状人数,分析躯体化症状与焦虑、抑郁的相关性,统计不同躯体化症状发生频率的分布情况。结果 50例具有躯体化症状的肺癌患者中,存在焦虑抑郁情绪的患者有43例,仅焦虑、仅抑郁及焦虑合并抑郁的患病率分别为10%、10%、66%,其中躯体化症状程度越高,焦虑合并抑郁的检出率越高。躯体化症状与焦虑、抑郁的相关分析显示,PHQ-15总分、PHQ-15阳性症状数目与HAMA得分（r=0.752,P〈0.001;r=0.710,P〈0.001）、HAMD得分（r=0.648,P〈0.001;r=0.618,P〈0.001）呈显著正相关。具有躯体化症状的肺癌患者临床症状出现频率由高到低依次是疲劳（96%）、虚弱感（88%）、睡眠障碍（84%）、头晕（82%）、肢体或关节疼痛（80%）等;不同性别肺癌患者之间的躯体化症状比较差异无统计学意义（P〉0.05）。结论具有躯体化症状的肺癌患者焦虑、抑郁常见,躯体化症状与焦虑、抑郁密切相关,此类患者最常见的临床症状为非特异性全身不适症状。
Bibliography:Lung neoplasms;Somatization symptoms;Anxiety and depression
Background and objective Lung cancer is a serious threat to human health and its morbidity and mortality in recent years has always been ranked first in the country. Lung cancer patients are often associated with anxiety,depression and other emotional problems, and anxiety, depression and other emotional problems will further lead to a series of somatic symptoms. At present, we lack the clinical understanding of somatization symptoms in patients with lung cancer and related clinical studies are not too much. This research is to study the features of clinical manifestation of lung cancer patients with somatization symptoms and correlative analysis between anxiety, depression and somatization symptoms in medical on-cology department of general hospital. Methods Lung cancer patients who met somatization symptoms diagnostic standard were assessed with the self-constructed somatic symptoms investigation questionnaire, the Chinese version of the Patient Hea
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2017.07.06