Brief Report: Childhood Disintegrative Disorder as a Likely Manifestation of Vitamin B12 Deficiency

• Published in: Journal of autism and developmental disorders Vol. 43; no. 9; pp. 2207 - 2210
• Main Authors: Malhotra, Savita, Subodh, B. N., Parakh, Preeti, Lahariya, Sanjay
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2013; Springer; Springer Nature B.V
• Subjects: Adolescent; Age; Anatomy; Anemias. Hemoglobinopathies; Autism; Behavioral Science and Psychology; Biological and medical sciences; Brief Report; Care and treatment; Case Studies; Child; Child & adolescent psychiatry; Child and School Psychology; Child clinical studies; Child Development; Child Development Disorders, Pervasive - drug therapy; Child Development Disorders, Pervasive - etiology; Childhood disintegrative disorder; Developmental Delays; Developmental disorders; Diagnosis; Diseases; Diseases of red blood cells; Economic Status; Etiology; Eye contact; Families & family life; Family (Sociological Unit); Hematologic and hematopoietic diseases; Homocysteine; Humans; Infantile autism; Male; Mass spectrometry; Measurement Techniques; Medical Education; Medical Evaluation; Medical sciences; Mental Disorders; Metabolic diseases; Neurology; Neurosciences; Nutrition; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...); Pacing; Pediatrics; Physical Examinations; Psychiatry; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Public Health; Regression (Psychology); Scientific imaging; Treatment Outcome; Vitamin B 12 - therapeutic use; Vitamin B 12 Deficiency - complications; Vitamin B 12 Deficiency - drug therapy; Vitamin B12 deficiency; Autism; Hyperhomocysteinemia; Childhood disintegrative disorder; Vitamin B12 deficiency; Immunopathology; Atrophic gastritis; Nutrition disorder; Vitamin deficiency; Autoimmune disease; Hemopathy; Developmental disorder; B-Vitamins; Biermer disease; Cyanocobalamin; Metabolic disorder; Malnutrition; Nutritional status
• ISSN: 0162-3257; 1573-3432
• DOI: 10.1007/s10803-013-1762-6

Childhood disintegrative disorder is a rare disorder, characterized by regression of acquired skills after a period of normal development. The case of childhood disintegrative disorder presented here was found to have vitamin B12 deficiency and hyperhomocysteinemia on extensive evaluation to find a probable cause for regression. This case illustrates the need for a thorough evaluation of all cases of childhood disintegrative disorder so that treatable causes of regression, like vitamin B12 deficiency, are not missed.