The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation

• Published in: Journal of Immunology Research Vol. 2018; no. 2018; pp. 1 - 8
• Main Authors: Frydecka, Irena, Kyrcz-Krzemien, Slawomira, Partyka, Anna, Pawlak-Adamska, E., Dzierzak-Mietla, Monika, Chrobot, Karolina, Markiewicz, Miroslaw, Karabon, L., Koclega, Anna
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; Hindawi Limited; Wiley
• Subjects: Acute Disease; Adult; Antigens; Antithymocyte globulin; Asthma; B7-2 Antigen - genetics; Bone marrow; Cancer; CD28 antigen; CD86 antigen; CTLA-4 Antigen - genetics; CTLA-4 protein; Deoxyribonucleic acid; DNA; Donors; Female; Gene expression; Gene polymorphism; Genes; Genetic diversity; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genotype; Genotypes; Graft vs Host Disease - genetics; Haplotypes; Hematologic Neoplasms - mortality; Hematologic Neoplasms - therapy; Hematology; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Humans; Immune response; Immune Tolerance - genetics; Immunology; Leukemia; Male; Medical research; Operating systems (Software); Polymorphism, Single Nucleotide; Recurrence; Rheumatoid arthritis; Risk factors; Single-nucleotide polymorphism; Stem cell transplantation; Stem cells; Studies; Survival Analysis; Transplantation; Transplantation, Homologous; Transplants & implants; Treatment Outcome; Poland
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2018/3826989

CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation (alloHSCT). Therefore, we postulate that CD86 gene variations might influence the outcome after alloHSCT. Altogether, 295 adult patients (pts) undergoing related (105 pts) and unrelated (190 pts) donor-matched HSCT were genotyped for the following CD86 gene polymorphisms: rs1129055, rs9831894, and rs2715267. Moreover, the donors’ rs1129055 polymorphism was determined. None of the investigated SNPs alone were associated with aGvHD and rate of relapse. However, we showed that rs2715267 SNP influenced overall survival (OS) after alloHSCT. The 24-month OS for the rs271526GG recipients was worse than that for the recipients possessing T allelle (TT or GT genotypes) (p=0.009). Moreover, analysis of gene-gene interaction between CD86 and CTLA-4 showed that having both the A allele for CD86 rs1129055 and the CTLA-4 CT60GG genotype in recipients increased the risk of aGvHD about 3.5 times. Interestingly, the donors’ rs1129055GG genotype and the recipients’ CT60GG genotype also increased the risk of aGvHD about 2.7-fold. We postulate that recipients’ CD86 gene polymorphisms influence the overall survival after alloHSCT and, together with CTLA-4 polymorphisms, might be considered a risk factor for aGvHD.