Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury

Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Male Sprague-Dawley ra...

Full description

Saved in:
Bibliographic Details
Published inPharmaceutical biology Vol. 61; no. 1; pp. 1054 - 1064
Main Authors Hu, En, Li, Teng, Li, Zhilin, Su, Hong, Yan, Qiuju, Wang, Lei, Li, Haigang, Zhang, Wei, Tang, Tao, Wang, Yang
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 31.12.2023
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Animals
Axons
Biological Sciences
brain damage
Brain Injuries, Traumatic - drug therapy
Brain-Derived Neurotrophic Factor
Carthamus tinctorius
Chalcone - pharmacology
Citrulline
cortex
Doublecortin protein
fluorescent antibody technique
growth-associated protein 43
Hippocampus
Immunofluorescence
Inflammation
ingredients
Male
males
Metabolism
Metabolites
Metabolomics
Nerve Regeneration
Network pharmacology
Neurogenesis
Ornithine
pharmacology
Phenylalanine
Quinones - pharmacology
Rats
Rats, Sprague-Dawley
Regeneration
signal transducer and activator of transcription 3
signal transduction
Stat3 protein
therapeutics
Traditional Chinese medicine
transactivators
Traumatic brain injury
Tryptophan
tyrosine
cortex
hippocampus
traditional Chinese medicine
Network pharmacology
growth-associated protein 43
signal transducer and activator of transcription 3
brain-derived neurotrophic factor
Online AccessGet full text

Cover

Abstract Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence. HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl's body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in 'arginine metabolism' and 'phenylalanine, tyrosine and tryptophan metabolism' including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus. HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
AbstractList AbstractContext Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.Objective To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration.Materials and methods Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl’s staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence.Results HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl’s body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in ‘arginine metabolism’ and ‘phenylalanine, tyrosine and tryptophan metabolism’ including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus.Discussion and conclusions HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
ContextHydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.ObjectiveTo explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration.Materials and methodsMale Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl’s staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence.ResultsHSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl’s body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in ‘arginine metabolism’ and ‘phenylalanine, tyrosine and tryptophan metabolism’ including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus.Discussion and conclusionsHSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl’s staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence. HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl’s body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in ‘arginine metabolism’ and ‘phenylalanine, tyrosine and tryptophan metabolism’ including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus. HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.CONTEXTHydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration.OBJECTIVETo explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration.Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence.MATERIALS AND METHODSMale Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence.HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl's body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in 'arginine metabolism' and 'phenylalanine, tyrosine and tryptophan metabolism' including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus.RESULTSHSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl's body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in 'arginine metabolism' and 'phenylalanine, tyrosine and tryptophan metabolism' including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus.HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.DISCUSSION AND CONCLUSIONSHSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower ( L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence. HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl's body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in 'arginine metabolism' and 'phenylalanine, tyrosine and tryptophan metabolism' including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus. HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) were used to evaluate the effects of HSYA on TBI at the 14th day. Next, the effectors of HSYA on post-TBI neurogenesis and axon regeneration were screened out by pathology-specialized network pharmacology and untargeted metabolomics. Then, the core effectors were validated by immunofluorescence. HSYA alleviated mNSS, foot fault rate, inflammatory cell infiltration, and Nissl's body loss. Moreover, HSYA increased not only hippocampal DCX but also cortical Tau1 and DCX following TBI. Metabolomics demonstrated that HSYA significantly regulated hippocampal and cortical metabolites enriched in 'arginine metabolism' and 'phenylalanine, tyrosine and tryptophan metabolism' including l-phenylalanine, ornithine, l-(+)-citrulline and argininosuccinic acid. Network pharmacology suggested that neurotrophic factor (BDNF) and signal transducer and activator of transcription 3 (STAT3) were the core nodes in the HSYA-TBI-neurogenesis and axon regeneration network. In addition, BDNF and growth-associated protein 43 (GAP43) were significantly elevated following HSYA treatment in the cortex and hippocampus. HSYA may promote TBI recovery by facilitating neurogenesis and axon regeneration through regulating cortical and hippocampal metabolism, BDNF and STAT3/GAP43 axis.
Author Wang, Yang
Su, Hong
Yan, Qiuju
Zhang, Wei
Hu, En
Wang, Lei
Li, Haigang
Tang, Tao
Li, Teng
Li, Zhilin
Author_xml – sequence: 1
  givenname: En
  surname: Hu
  fullname: Hu, En
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 2
  givenname: Teng
  surname: Li
  fullname: Li, Teng
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 3
  givenname: Zhilin
  surname: Li
  fullname: Li, Zhilin
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 4
  givenname: Hong
  surname: Su
  fullname: Su, Hong
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 5
  givenname: Qiuju
  surname: Yan
  fullname: Yan, Qiuju
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 6
  givenname: Lei
  surname: Wang
  fullname: Wang, Lei
  organization: Department of Respiratory Diseases, Xiangxiang People's Hospital
– sequence: 7
  givenname: Haigang
  surname: Li
  fullname: Li, Haigang
  organization: Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University
– sequence: 8
  givenname: Wei
  surname: Zhang
  fullname: Zhang, Wei
  organization: The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine
– sequence: 9
  givenname: Tao
  surname: Tang
  fullname: Tang, Tao
  organization: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
– sequence: 10
  givenname: Yang
  surname: Wang
  fullname: Wang, Yang
  organization: Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine, Xiangya Hospital, Central South University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37416997$$D View this record in MEDLINE/PubMed
BookMark eNqFUstOHDEQHEVE4ZF8QiJLueSyxI_x2FYOCUJ5IBHlwt3q8bTBq1mb2DPAfkN-Ol4WUOAQTrarq8rtdu03OzFFbJq3jB4yqulHJrSmnJpDTrk45JwbocyLZo-ptl1Ixrqduq-cxYa02-yXsqSUSiHkq2ZXqJZ1xqi95s9PnKBPY1oFV0jGK4SxkOkCCXqPbiokeXKxHnK6WRfwfkyZrHEc0zU5IimSiHNO5xixhEIgDgRuKppxA2WYQj2AnzATvLnEHFYYJxjJlGFe1aojfYYQSYjLOa9fNy99vR3f3K0Hzdm3r2fHPxanv76fHB-dLpw03bSQsgfT-oEKz7TSnVMo9NBRLaWnum85UGj7irey7XruuWRgFIgOBwFOi4PmZGs7JFjay9oU5LVNEOwtkPK5hVx7G9F2VWO46jqFuu2UMmgMOC-lRqdbN1Svz1uvy7lf4eDq8zKMj0wfV2K4sOfpyjIqRP00Wh0-3Dnk9HvGMtlVKK5OGCKmuVjBpKh_qox6lsq1kFyxtgbioHn_hLpMc451qpYbpmSrjZSV9e7f7h_avo9HJcgtweVUSkb_QGHUbmJo72NoNzG0dzGsuk9PdC5Mt2moQwjjs-ovW3WIPuUVXKc8DnaCdQ2fzxBd2IzlvxZ_AREj9_o
CitedBy_id crossref_primary_10_1002_jbt_70027
crossref_primary_10_1016_j_ejmech_2025_117350
crossref_primary_10_1007_s11655_024_4004_1
crossref_primary_10_1186_s13020_024_01001_0
crossref_primary_10_2147_DDDT_S450895
crossref_primary_10_1016_j_neuroscience_2025_02_007
crossref_primary_10_1515_znc_2024_0243
crossref_primary_10_1016_j_cbpc_2025_110122
crossref_primary_10_1080_87559129_2024_2414181
crossref_primary_10_3390_life15010071
crossref_primary_10_1097_WNR_0000000000001998
Cites_doi 10.1038/s41419-021-03503-3
10.1016/j.bbr.2021.113136
10.1016/j.expneurol.2015.03.020
10.1089/neu.2014.3680
10.1146/annurev.pharmtox.48.113006.094715
10.1038/cddis.2013.310
10.1111/cns.12162
10.3390/biomedicines8100389
10.3389/fphar.2017.00264
10.1371/journal.pone.0088703
10.1155/2020/7805393
10.1001/jamaneurol.2021.2043
10.1523/JNEUROSCI.3457-15.2016
10.1016/j.expneurol.2006.05.034
10.3390/ijms232113000
10.3389/fncel.2018.00371
10.1080/10286020903510636
10.3389/fphar.2020.559618
10.3109/13880209.2013.877491
10.1007/s13311-018-0631-6
10.1007/s11011-015-9763-0
10.1080/00498254.2019.1668983
10.3892/mmr.2016.5720
10.3389/fimmu.2022.855701
10.3389/fnins.2020.00876
10.3390/cells11152371
10.1186/s12974-017-0870-1
10.3390/ijms22126418
10.1016/j.mcn.2009.01.011
10.1001/jama.2020.8130
10.1590/ACB351202
10.1089/neu.2005.22.252
10.1016/j.febslet.2006.05.026
10.1016/j.expneurol.2020.113372
10.1007/s00134-022-06702-4
10.3389/fphar.2020.01265
10.3390/ijms22073582
10.1038/nrn3407
10.1016/j.jep.2010.02.023
10.1016/j.brainres.2014.03.036
10.1007/s10571-009-9455-6
10.1038/341149a0
10.1016/j.csbj.2021.01.033
10.1016/j.expneurol.2020.113462
10.1016/j.expneurol.2016.03.004
10.1016/j.brainres.2016.04.030
10.1016/S1474-4422(17)30279-X
ContentType Journal Article
Copyright 2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. 2023
2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. 2023 Xiangya Hospital of Central South University
Copyright_xml – notice: 2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. 2023
– notice: 2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 Xiangya Hospital of Central South University. Published by Informa UK Limited, trading as Taylor & Francis Group. 2023 Xiangya Hospital of Central South University
DBID 0YH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FR3
FYUFA
GHDGH
K9.
M0S
P64
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
7S9
L.6
5PM
DOA
DOI 10.1080/13880209.2023.2229379
DatabaseName Taylor & Francis Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Technology Research Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Central China
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Central (New)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
Publicly Available Content Database
AGRICOLA
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate E. Hu et al
EISSN 1744-5116
EndPage 1064
ExternalDocumentID oai_doaj_org_article_66ed927667e846779e99acf558ec84cd
PMC10332220
37416997
10_1080_13880209_2023_2229379
2229379
Genre Research Article
Journal Article
GroupedDBID ---
00X
0YH
123
29O
4.4
7X7
8FI
8FJ
AAHBH
ABDBF
ABUWG
ACGEJ
ACGFS
ACUHS
ADBBV
ADCVX
ADRBQ
ADXPE
AENEX
AFKRA
AFKVX
AJWEG
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ARJSQ
BABNJ
BCNDV
BENPR
CCPQU
COF
CS3
DU5
EAL
EAP
EBD
EBS
EMK
EMOBN
EPL
EPT
EST
ESX
F5P
FYUFA
GROUPED_DOAJ
H13
HMCUK
HYE
HZ~
KTTOD
M4Z
ML~
O9-
P2P
PIMPY
PROAC
Q~Q
RPM
SV3
TDBHL
TFDNU
TFL
TFW
TUS
UKHRP
V1S
~1N
AAYXX
CITATION
PHGZM
PHGZT
53G
5VS
AALIY
AWYRJ
BPHCQ
BVXVI
CAG
CGR
CUY
CVF
CZDIS
DRXRE
DWTOO
ECM
EIF
EJD
M44
NPM
NUSFT
PQQKQ
3V.
7XB
8FD
8FK
AZQEC
DWQXO
FR3
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
7X8
7S9
L.6
5PM
PUEGO
ID FETCH-LOGICAL-c596t-55ba94fd03f18786c7e38d60855f08b42a0a4b86c4546b2f251a97a36ed3ac83
IEDL.DBID 0YH
ISSN 1388-0209
1744-5116
IngestDate Wed Aug 27 01:32:01 EDT 2025
Thu Aug 21 18:37:13 EDT 2025
Wed Jul 02 04:46:37 EDT 2025
Thu Jul 10 19:32:43 EDT 2025
Mon Jun 30 11:59:09 EDT 2025
Thu Jan 02 22:43:56 EST 2025
Tue Jul 01 03:51:28 EDT 2025
Thu Apr 24 23:02:53 EDT 2025
Wed Dec 25 09:06:01 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords cortex
hippocampus
traditional Chinese medicine
Network pharmacology
growth-associated protein 43
signal transducer and activator of transcription 3
brain-derived neurotrophic factor
Language English
License open-access: http://creativecommons.org/licenses/by/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c596t-55ba94fd03f18786c7e38d60855f08b42a0a4b86c4546b2f251a97a36ed3ac83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Supplemental data for this article can be accessed online at https://doi.org/10.1080/13880209.2023.2229379.
OpenAccessLink https://www.tandfonline.com/doi/abs/10.1080/13880209.2023.2229379
PMID 37416997
PQID 2917548955
PQPubID 3933390
PageCount 11
ParticipantIDs proquest_miscellaneous_2835271402
proquest_journals_2917548955
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10332220
crossref_citationtrail_10_1080_13880209_2023_2229379
proquest_miscellaneous_3153174797
pubmed_primary_37416997
doaj_primary_oai_doaj_org_article_66ed927667e846779e99acf558ec84cd
informaworld_taylorfrancis_310_1080_13880209_2023_2229379
crossref_primary_10_1080_13880209_2023_2229379
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-12-31
PublicationDateYYYYMMDD 2023-12-31
PublicationDate_xml – month: 12
  year: 2023
  text: 2023-12-31
  day: 31
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Abingdon
PublicationTitle Pharmaceutical biology
PublicationTitleAlternate Pharm Biol
PublicationYear 2023
Publisher Taylor & Francis
Taylor & Francis Ltd
Taylor & Francis Group
Publisher_xml – name: Taylor & Francis
– name: Taylor & Francis Ltd
– name: Taylor & Francis Group
References e_1_3_5_29_1
e_1_3_5_27_1
e_1_3_5_25_1
e_1_3_5_23_1
e_1_3_5_44_1
e_1_3_5_46_1
Zhang J (e_1_3_5_51_1) 2022; 36
e_1_3_5_48_1
e_1_3_5_3_1
e_1_3_5_40_1
e_1_3_5_42_1
e_1_3_5_9_1
e_1_3_5_21_1
e_1_3_5_5_1
Chen S (e_1_3_5_6_1) 2019; 19
e_1_3_5_7_1
e_1_3_5_18_1
e_1_3_5_39_1
e_1_3_5_16_1
e_1_3_5_37_1
e_1_3_5_14_1
e_1_3_5_35_1
e_1_3_5_12_1
Paxinos G (e_1_3_5_33_1) 2007
e_1_3_5_50_1
e_1_3_5_52_1
e_1_3_5_54_1
e_1_3_5_10_1
e_1_3_5_31_1
e_1_3_5_28_1
e_1_3_5_26_1
Chinese Pharmacopoeia Commission (e_1_3_5_8_1) 2020
e_1_3_5_24_1
e_1_3_5_22_1
e_1_3_5_45_1
e_1_3_5_47_1
e_1_3_5_49_1
e_1_3_5_2_1
e_1_3_5_43_1
e_1_3_5_20_1
e_1_3_5_4_1
e_1_3_5_17_1
e_1_3_5_38_1
e_1_3_5_13_1
e_1_3_5_36_1
e_1_3_5_11_1
e_1_3_5_34_1
e_1_3_5_19_1
Huebner EA (e_1_3_5_15_1) 2009; 48
e_1_3_5_53_1
Shu X (e_1_3_5_41_1) 2008; 5
e_1_3_5_32_1
e_1_3_5_30_1
References_xml – ident: e_1_3_5_37_1
  doi: 10.1038/s41419-021-03503-3
– ident: e_1_3_5_42_1
  doi: 10.1016/j.bbr.2021.113136
– ident: e_1_3_5_5_1
  doi: 10.1016/j.expneurol.2015.03.020
– ident: e_1_3_5_31_1
  doi: 10.1089/neu.2014.3680
– ident: e_1_3_5_18_1
  doi: 10.1146/annurev.pharmtox.48.113006.094715
– ident: e_1_3_5_20_1
  doi: 10.1038/cddis.2013.310
– ident: e_1_3_5_7_1
  doi: 10.1111/cns.12162
– volume-title: The rat brain in stereotaxic coordinates
  year: 2007
  ident: e_1_3_5_33_1
– ident: e_1_3_5_17_1
  doi: 10.3390/biomedicines8100389
– ident: e_1_3_5_32_1
  doi: 10.3389/fphar.2017.00264
– ident: e_1_3_5_50_1
  doi: 10.1371/journal.pone.0088703
– ident: e_1_3_5_19_1
  doi: 10.1155/2020/7805393
– volume: 5
  start-page: 1051
  year: 2008
  ident: e_1_3_5_41_1
  article-title: [Observational study on the distribution of traditional Chinese medicine syndrome after traumatic brain injury]
  publication-title: Chin Arch Trad Chin Med
– ident: e_1_3_5_25_1
  doi: 10.1001/jamaneurol.2021.2043
– ident: e_1_3_5_16_1
  doi: 10.1523/JNEUROSCI.3457-15.2016
– ident: e_1_3_5_38_1
  doi: 10.1016/j.expneurol.2006.05.034
– ident: e_1_3_5_10_1
  doi: 10.3390/ijms232113000
– ident: e_1_3_5_49_1
  doi: 10.3389/fncel.2018.00371
– ident: e_1_3_5_4_1
  doi: 10.1080/10286020903510636
– ident: e_1_3_5_22_1
  doi: 10.3389/fphar.2020.559618
– ident: e_1_3_5_24_1
  doi: 10.3109/13880209.2013.877491
– ident: e_1_3_5_30_1
  doi: 10.1007/s13311-018-0631-6
– ident: e_1_3_5_35_1
  doi: 10.1007/s11011-015-9763-0
– ident: e_1_3_5_40_1
  doi: 10.1080/00498254.2019.1668983
– ident: e_1_3_5_44_1
  doi: 10.3892/mmr.2016.5720
– volume-title: Chinese Pharmacopoeia
  year: 2020
  ident: e_1_3_5_8_1
– volume: 36
  start-page: e22305
  year: 2022
  ident: e_1_3_5_51_1
  article-title: The metabolomic profiling identifies N, N-dimethylglycine as a facilitator of dorsal root ganglia neuron axon regeneration after injury
  publication-title: FASEB J
– ident: e_1_3_5_54_1
  doi: 10.3389/fimmu.2022.855701
– ident: e_1_3_5_53_1
  doi: 10.3389/fnins.2020.00876
– ident: e_1_3_5_2_1
  doi: 10.3390/cells11152371
– ident: e_1_3_5_34_1
  doi: 10.1186/s12974-017-0870-1
– volume: 19
  start-page: 3009
  year: 2019
  ident: e_1_3_5_6_1
  article-title: Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis
  publication-title: Mol Med Rep
– volume: 48
  start-page: 339
  year: 2009
  ident: e_1_3_5_15_1
  article-title: Axon regeneration in the peripheral and central nervous systems
  publication-title: Results Probl Cell Differ
– ident: e_1_3_5_28_1
  doi: 10.3390/ijms22126418
– ident: e_1_3_5_29_1
  doi: 10.1016/j.mcn.2009.01.011
– ident: e_1_3_5_39_1
  doi: 10.1001/jama.2020.8130
– ident: e_1_3_5_48_1
  doi: 10.1590/ACB351202
– ident: e_1_3_5_12_1
  doi: 10.1089/neu.2005.22.252
– ident: e_1_3_5_13_1
  doi: 10.1016/j.febslet.2006.05.026
– ident: e_1_3_5_36_1
  doi: 10.1016/j.expneurol.2020.113372
– ident: e_1_3_5_27_1
  doi: 10.1007/s00134-022-06702-4
– ident: e_1_3_5_3_1
  doi: 10.3389/fphar.2020.01265
– ident: e_1_3_5_11_1
  doi: 10.3390/ijms22073582
– ident: e_1_3_5_47_1
  doi: 10.1038/nrn3407
– ident: e_1_3_5_43_1
  doi: 10.1016/j.jep.2010.02.023
– ident: e_1_3_5_52_1
  doi: 10.1016/j.brainres.2014.03.036
– ident: e_1_3_5_9_1
  doi: 10.1007/s10571-009-9455-6
– ident: e_1_3_5_21_1
  doi: 10.1038/341149a0
– ident: e_1_3_5_23_1
  doi: 10.1016/j.csbj.2021.01.033
– ident: e_1_3_5_14_1
  doi: 10.1016/j.expneurol.2020.113462
– ident: e_1_3_5_26_1
  doi: 10.1016/j.expneurol.2016.03.004
– ident: e_1_3_5_46_1
  doi: 10.1016/j.brainres.2016.04.030
– ident: e_1_3_5_45_1
  doi: 10.1016/S1474-4422(17)30279-X
SSID ssj0005335
Score 2.4916346
Snippet Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI)...
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower ( L., [Asteraceae]) for traumatic brain injury (TBI) treatment. To explore the...
ContextHydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI)...
AbstractContext Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
informaworld
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1054
SubjectTerms Animals
Axons
Biological Sciences
brain damage
Brain Injuries, Traumatic - drug therapy
Brain-Derived Neurotrophic Factor
Carthamus tinctorius
Chalcone - pharmacology
Citrulline
cortex
Doublecortin protein
fluorescent antibody technique
growth-associated protein 43
Hippocampus
Immunofluorescence
Inflammation
ingredients
Male
males
Metabolism
Metabolites
Metabolomics
Nerve Regeneration
Network pharmacology
Neurogenesis
Ornithine
pharmacology
Phenylalanine
Quinones - pharmacology
Rats
Rats, Sprague-Dawley
Regeneration
signal transducer and activator of transcription 3
signal transduction
Stat3 protein
therapeutics
Traditional Chinese medicine
transactivators
Traumatic brain injury
Tryptophan
tyrosine
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQlNdCQYOEemq22djx41gQVYVU1MMi9RbZjt0uqrKoyQr2N_RPM5PHNluB9sJ17EixZzKPePx9jH1MvXOZ9h7LElcmogxp4oKaJQYdo5alFzrSf8jzb_Lsu_h6mV-OqL6oJ6yDB-427ljKUJpMSakChUplgjHWxzzXwWvhS_K-GPOGYmpo7uAtteaMox1gQmSGuzs6PSYZiaZEHD4lOmtOfVyjqNSC9z-ALv1bAvqwj3IUmE6fsid9Rgkn3UqesUeh2meHFx0k9foI5vc3rOojOISLe7Dq9XN2dx4atIMbupxcA-E5oT0CZoXQd3rAMsL1uqRul9rGiOU9rOnA5hecwLKCFg_zihzmogZblWB_o_Q2XLVw1qR1aGnIYUwlALiOVYsVC44oKmBR_UDdvmDz0y_zz2dJT9CQ-NzIJslzZ42IZcrjTCstvQpcl5Ja32KqnchsaoVDuciFdFnEXMoaZTmqlFuv-Uu2Vy2r8JqBc1hYWjrz9FGgE0JVWyVjrlyIOrNuwsSgn8L34OXEoXFTzHqM00GtBam16NU6YdPNYz879I5dD3wi5W8mE_h2K0CTLHqTLHaZ5ISZsekUTfvvJXZEKQXf8QIHg50VvTepiwxraqwsTZ5P2IfNMPoBOtyxVViucA6l0oS-mP17DsfwhhWoMmrCXnWmu1kpp9Tc0IjeMuqtrdgeqRbXLR75LOV0Xpe--R-b95Y9pv3osDQP2F5zuwrvMO9r3Pv2E_8DMrNTNA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9QwELagXLgg3iwUZCTUU7PNxo4fJ1QQVYVU1MMi7S2yHXvbqkrKZlewv4E_zYzjfVVAr7Yj2Znx-LM9_j5CPuTO2kI5B9sSW2e89nlmvRxlGgKjErXjKuA55Nk3cfqdf52Uk3Tg1qW0ylVMjIG6bh2ekR8VsK8AdK3L8uPNjwxVo_B2NUlo3CcPkLoMU7rkRG5SPFgU2Bwx8AaARXr1gkflR1iGRUOUDx-iqDXDbK6ttSlS-N8iMP0bDL2dTbm1PJ08Jo8SrqTHvSM8Ifd885QcnPfE1MtDOt68s-oO6QE931BWL5-R32d-Dt5wjU-UO4qsTuCVFLAhTfketA30YlljzktnQoBNPl3itc1PekzbhkZWzCmGzcuOmqam5heUzvw0klqj7WkUI6fbggIUxrGIjLHUolAFvWyuwMLPyfjky_jzaZZkGjJXajHPytIazUOdszBSUgknPVO1wAS4kCvLC5MbbqGcl1zYIgCiMloaJnzNjFPsBdlr2sa_ItRa2F4avPl0gUMoAmxkpAiltD6owtgB4Sv7VC5RmKOSxnU1SkynK7NWaNYqmXVAhuvPbnoOj7s--ITGXzdGCu5Y0M6mVZrRlYD-60IKIT1iOKm91saFslTeKe7qAdHbrlPN4wlM6OVSKnZHB_ZXflalmNJVmxkwIO_X1RAN8IrHNL5dQBsE1MjBWPy7DYNFDvahUssBedm77nqkDAG6xhq149Q7v2K3prm8iKzko5zhrV3--v99f0Me4kh7rsx9sjefLfxbwHVz-y5O3j80KEqx
  priority: 102
  providerName: ProQuest
Title Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury
URI https://www.tandfonline.com/doi/abs/10.1080/13880209.2023.2229379
https://www.ncbi.nlm.nih.gov/pubmed/37416997
https://www.proquest.com/docview/2917548955
https://www.proquest.com/docview/2835271402
https://www.proquest.com/docview/3153174797
https://pubmed.ncbi.nlm.nih.gov/PMC10332220
https://doaj.org/article/66ed927667e846779e99acf558ec84cd
Volume 61
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LaxsxEBZtcuml9F23qVGh5JRN1yutHsekJJhCgikupKdF0kqOQ1gXr03r39A_3Rntrh-hIYdeDKuHWe2MRt9Io28I-ZQ6azPlHLgltkx46dPEejlINBhGJUrHVcB9yItLMfzOv17lXTRh3YZVog8dGqKIaKtxchtbdxFxnwdIYJKleM0kY8eYkJpJ_ZjsZ6itoNLpj-EmyoPFHJvYJcE-3SWe-_5mZ3mKLP53OEz_hUTvBlRurVDnz8jTFlrSk0YXnpNHvnpBDkcNN_XqiI43V63qI3pIRxvW6tVL8ufCL0AhbvGWck2R2AkUkwI8pG3IB50Fer0qMeylNiGAn09XeHLzi57QWUUjMeYELee0pvBpqfkNpXM_ibzWKH4a85HT7ZwCFMaxjKSx1GKuCjqtbkDIr8j4_Gz8ZZi0mRoSl2uxSPLcGs1DmbIwUFIJJz1TpcAYuJAqyzOTGm6hnOdc2CwAqDJaGiZ8yYxT7DXZq2aVf0uoteBhGjz8dIGDNQJ4ZKQIubQ-qMzYHuGdfArXsphjMo3bYtCSnXZiLVCsRSvWHjled_vZ0Hg81OEUhb9ujCzcsWA2nxTtpC4EvL_OpBDSI4yT2mttXMhz5Z3iruwRva06xSJuwoQmY0rBHniBg07Pitas1EUGzjW4mDrPe-TjuhoMAp7ymMrPltAGMTXSMGb3t2GwzoErKrXskTeN6q5HyhCja6xRO0q98yl2a6rpdSQmH6QMD-7Sd_8x7vfkCT42XJoHZG8xX_oPgPsWth9nNvzKK9kn-6dnl6Nv_biH8hfm6FNk
linkProvider Taylor & Francis
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELZKeoAL4k2ggJGgp266We_DPiDUQquUNlGEgtSbZXvtNCjaLXmo5DfwW_iPzOwjjwroqdexN7Iz4_GMPf4-Qt75RuuAGwNpiU69MLW-p23S9gQ4Rh6nJuQOzyG7vbjzLfxyHp1vkd_1Wxgsq6x9YuGo09zgGfl-AHkFRNciij5e_vCQNQpvV2sKjdIsTu3iClK26YeTz6Df90FwfDT41PEqVgHPRCKeeVGklQhd6jPX5gmPTWIZT2Os13I-12GgfBVqkIdRGOvAQQCgRKJYbFOmDGfws3fIdsggk2mQ7cOjXv_rqqaEFYyebQbmB3GYqJ8McX8fZShqIV95C1m0GZaPrW2GBWfANcTUv8W918s31_bD4wfkfhXI0oPS8h6SLZs9Irv9Egl7sUcHq4dd0z26S_srjOzFY_Kra2dgfmN8Ez2lCCMFy4BCMEqrAhOaO3qxSLHIZqqcG-cTusB7oit6QPOMFjCcQ_TToylVWUrVT5BO7LBA0UZjowX7OV1nMKAwj3kBUUs1MmPQUfYdTOoJGdyGBp-SRpZn9jmhWkM-q_Cq1bgQfB8EYyqJXZRo63igdJOEtX6kqTDTkbpjLNsVtGqtVolqlZVam6S1_OyyBA256YNDVP6yM2J-F4J8MpSVC5ExjF8ESRwnFoPGRFghlHFRxK3hoUmbRKybjpwVRz6u5GeR7IYB7NR2JisnNpWrJdckb5fN4H7wTkllNp9DH4zgEfQx-HcfBrsqJL6JSJrkWWm6y5kyzAgEtvANo974KzZbstFFAYPe9hleE_ov_j_2N-RuZ9A9k2cnvdOX5B7OugTq3CGN2WRuX0FQOdOvq6VMibxl5_EHNQOHqg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZbxMxELagSIgXxE2ggJFQn7pls15fj-WIwtEqD0GCJ8v22mlQtamyiSC_gT_NzB45Kqo-8OpjtfaMx9_Y428IeZN65zLlPbglrkjyIqSJC7KfaDCMShQ-VxHPIU9OxfBb_vk776IJqzasEn3o2BBF1LYaF_dFEbuIuLd9JDDJUnxmkrEjTEjNpL5JbnEFez2odPpjuInyYHWOTeySYJ_uEc9Vn9nZnmoW_0scpv9CopcDKrd2qME9creFlvS40YX75EYoH5CDUcNNvTqk481Tq-qQHtDRhrV69ZD8OQkLUIhzfKVcUSR2AsWkAA9pG_JBZ5GerQoMe6lsjODn0xXe3Pyix3RW0poYc4KWc1pRmFpqf0PpPExqXmsUP63zkdPtnAIUxrGsSWOpw1wVdFr-BCE_IuPBx_H7YdJmakg812KRcO6szmORsthXUgkvA1OFwBi4mCqXZza1uYPynOfCZRFAldXSMhEKZr1ij8leOSvDU0KdAw_T4uWnjzlYI4BHVorIpQtRZdb1SN7Jx_iWxRyTaZybfkt22onVoFhNK9YeOVp3u2hoPK7r8A6Fv26MLNx1wWw-Me2iNgL-X2dSCBkQxkkdtLY-cq6CV7kvekRvq45Z1IcwscmYYtg1P7Df6ZlpzUplMnCuwcXUnPfI63U1GAS85bFlmC2hDWJqpGHMrm7DYJ8DV1Rq2SNPGtVdj5QhRtdYo3aUemcqdmvK6VlNTN5PGV7cpc_-Y9yvyO3Rh4H5-un0y3NyB2saWs19sreYL8MLgIAL97Je5H8BbyBSlA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Metabolomics+reveals+the+effects+of+hydroxysafflor+yellow+A+on+neurogenesis+and+axon+regeneration+after+experimental+traumatic+brain+injury&rft.jtitle=Pharmaceutical+biology&rft.au=Hu%2C+En&rft.au=Li%2C+Teng&rft.au=Li%2C+Zhilin&rft.au=Su%2C+Hong&rft.date=2023-12-31&rft.issn=1744-5116&rft.eissn=1744-5116&rft.volume=61&rft.issue=1&rft.spage=1054&rft_id=info:doi/10.1080%2F13880209.2023.2229379&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1388-0209&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1388-0209&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1388-0209&client=summon