Absence of Association or Genetic Linkage between the Angiotensin-Converting–Enzyme Gene and Left Ventricular Mass

Left ventricular hypertrophy is recognized as a major independent risk factor for morbidity and mortality from cardiovascular causes. 1 – 4 Blood pressure, obesity, and age are important determinants of left ventricular mass 2 ; however, they account only for part of the observed variance. 5 Evidenc...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 334; no. 16; pp. 1023 - 1028
Main Authors Lindpaintner, Klaus, Lee, MinAe, Larson, Martin G, Rao, V. Srinivas, Pfeffer, Marc A, Ordovas, Jose M, Schaefer, Ernst J, Wilson, Alexander F, Wilson, Peter W.F, Vasan, Ramachandran S, Myers, Richard H, Levy, Daniel
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 18.04.1996
Subjects
Adult
Algorithms
Base Sequence
Biological and medical sciences
Blood pressure
Cardiology. Vascular system
Endocardial and cardiac valvular diseases
Female
Gene Frequency
Genetic Linkage
Genetic testing
Genotype
Genotype & phenotype
Growth Hormone - genetics
Heart
Heart Ventricles - anatomy & histology
Heart Ventricles - diagnostic imaging
Humans
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - genetics
Linear Models
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Peptidyl-Dipeptidase A - genetics
Risk factors
Ultrasonography
Human
Echocardiography
Enzyme
Peptidyl-dipeptidase A
Cardiovascular disease
Hydrolases
Peptidyl-dipeptidases
Genotype
Gene expression
Proteinases
Left ventricle
Hypertrophy
Online AccessGet full text

Cover

More Information
Summary:Left ventricular hypertrophy is recognized as a major independent risk factor for morbidity and mortality from cardiovascular causes. 1 – 4 Blood pressure, obesity, and age are important determinants of left ventricular mass 2 ; however, they account only for part of the observed variance. 5 Evidence that left ventricular mass is a familial trait 6 – 10 suggests the influence of genetic factors; the absence of simple mendelian patterns of inheritance — except in rare syndromes 11 — identifies left ventricular mass as a complex phenotype that is influenced by interacting genetic and environmental factors. In humans the gene for angiotensin-converting enzyme (ACE) occurs in two . . .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199604183341604