Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin

• Published in: Cell research Vol. 20; no. 12; pp. 1386 - 1389
• Main Authors: Ding, Xia, Yan, Feng, Yao, Phil, Yang, Zhihong, Wan, Weihong, Wang, Xiwei, Liu, Jing, Gao, Xinjiao, Abrieu, Ariane, Zhu, Tongge, Zhang, Jiancun, Dou, Zhen, Yao, Xuebiao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2010; Nature Publishing Group
• Subjects: 631/80/103; 631/80/128; 631/80/641/1655; 631/92/613; Biomedical and Life Sciences; Cell Biology; Chromosomal Proteins, Non-Histone - antagonists & inhibitors; Chromosomal Proteins, Non-Histone - metabolism; Chromosomal Proteins, Non-Histone - physiology; Chromosomes, Human - metabolism; HeLa Cells; Heterocyclic Compounds, 3-Ring - chemistry; Heterocyclic Compounds, 3-Ring - pharmacology; Humans; letter-to-the-editor; Life Sciences; Microtubules - metabolism; Thioglycolates - chemistry; Thioglycolates - pharmacology; 小分子; 抑制剂; 有丝分裂; 染色体分离; 相互作用; 着丝粒; 驱动蛋白
• ISSN: 1001-0602; 1748-7838
• DOI: 10.1038/cr.2010.167

Dear Editor, Chromosome movements during mitosis are orches- trated primarily by the interaction of spindle microtu- bules with the kinetochore [1], the site for attachment of spindle microtubules to the centromere. The kinetochore has an active function in chromosomal segregation through microtubule-based motors located at or near it [1-2]. CENP-E is a microtubule-based kinesin motor [3],