The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?

• Published in: FEBS open bio Vol. 13; no. 4; pp. 586 - 596
• Main Authors: Bavis, Makayla M., Nicholas, Allison M., Tobin, Alexandria J., Christian, Sherri L., Brown, Robert J.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc; Wiley
• Subjects: Breast Cancer; Breast Neoplasms; breasts; Cell growth; Cell signaling; Datasets; energy; Enzymes; Epidermal growth factor; estrogen receptor; Estrogens; Fatty Acids; Fatty Acids - metabolism; Female; Gene expression; Genomes; Glucose; growth and development; Heparan sulfate; High density lipoprotein; human epidermal growth factor receptor 2; Human subjects; Humans; hydrolysis; Hypothesis; Kinases; Lipase; lipase maturation factor; Lipids; Lipoprotein lipase; Lipoprotein Lipase - metabolism; Lipoproteins; Meta-analysis; Metabolism; Metabolites; Phospholipids; progesterone receptor; Prognosis; Proteins; Software; Tissues; triacylglycerols; Triglycerides - metabolism; Tumor cells; Tumor Microenvironment; Tumor necrosis factor-TNF; Tumors; Canada; breast cancer; human epidermal growth factor receptor 2; estrogen receptor; lipase maturation factor; progesterone receptor; lipoprotein lipase
• ISSN: 2211-5463; 2211-5463
• DOI: 10.1002/2211-5463.13559

The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes for rapidly proliferating tumor cells. A significant quantity of fatty acids comes from the hydrolysis of lipoprotein triacylglycerols and phospholipids by lipoprotein lipase (LPL). The lipid obtained via LPL in the breast tumor microenvironment may thus promote breast tumor growth and development. In this hypothesis article, we introduce LPL, provide a meta‐analysis of RNAseq data showing that LPL is associated with poor prognosis, and explain how LPL might play a role in breast cancer prognosis over time. This hypothesis article introduces lipoprotein lipase (LPL), provides a meta‐analysis of LPL mRNA expression in breast cancer, and explores a possible role for LPL in breast cancer. Overall, we hypothesize that the lipid hydrolysis products that are generated from lipoproteins by LPL impact the breast cancer cell microenvironment, ultimately decreasing prognosis due to increased proliferation and metastasis.