Twenty-Five Years of Intracranial Pressure Monitoring After Severe Traumatic Brain Injury: A Retrospective, Single-Center Analysis

• Published in: Neurosurgery Vol. 85; no. 1; pp. E75 - E82
• Main Authors: Donnelly, Joseph, Czosnyka, Marek, Adams, Hadie, Cardim, Danilo, Kolias, Angelos G, Zeiler, Frederick A, Lavinio, Andrea, Aries, Marcel, Robba, Chiara, Smielewski, Peter, Hutchinson, Peter J A, Menon, David K, Pickard, John D, Budohoski, Karol P
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2019; Copyright by the Congress of Neurological Surgeons; Wolters Kluwer Health, Inc
• Subjects: Adolescent; Adult; Brain Injuries, Traumatic - physiopathology; Cerebrovascular Circulation - physiology; Cohort Studies; Female; Hemodynamics; Humans; Intracranial Pressure - physiology; Male; Medicin och hälsovetenskap; Middle Aged; Neurophysiological Monitoring - trends; Neurosurgery; Retrospective Studies; Traumatic brain injury; United Kingdom; United Kingdom; Autoregulation; Traumatic brain injury; Intracranial pressure; Cerebral hemodynamics; Outcome
• ISSN: 0148-396X; 1524-4040; 1524-4040
• DOI: 10.1093/neuros/nyy468

Abstract BACKGROUND Intracranial pressure (ICP) is a clinically important variable after severe traumatic brain injury (TBI) and has been monitored, along with clinical outcome, for over 25 yr in Addenbrooke's hospital, Cambridge, United Kingdom. This time period has also seen changes in management strategies with the implementation of protocolled specialist neurocritical care, expansion of neuromonitoring techniques, and adjustments of clinical treatment targets. OBJECTIVE To describe the changes in intracranial monitoring variables over the past 25 yr. METHODS Data from 1146 TBI patients requiring ICP monitoring were analyzed. Monitored variables included ICP, cerebral perfusion pressure (CPP), and the cerebral pressure reactivity index (PRx). Data were stratified into 5-yr epochs spanning the 25 yr from 1992 to 2017. RESULTS CPP increased sharply with specialist neurocritical care management (P < 0.0001) (introduction of a specific TBI management algorithm) before stabilizing from 2000 onwards. ICP decreased significantly over the 25 yr of monitoring from an average of 19 to 12 mmHg (P < 0.0001) but PRx remained unchanged. The mean number of ICP plateau waves and the number of patients developing refractory intracranial hypertension both decreased significantly. Mortality did not significantly change in the cohort (22%). CONCLUSION We demonstrate the evolving trends in neurophysiological monitoring over the past 25 yr from a single, academic neurocritical care unit. ICP and CPP were responsive to the introduction of an ICP/CPP protocol while PRx has remained unchanged. Graphical Abstract Graphical Abstract