Socio‐economic, behavioural, (neuro)psychological and clinical determinants of HRQoL in people living with HIV in Belgium: a pilot study

• Published in: Journal of the International AIDS Society Vol. 16; no. 1; pp. 18643 - n/a
• Main Authors: Degroote, Sophie, Vogelaers, Dirk P., Vermeir, Peter, Mariman, An, De Rick, Ann, Van Der Gucht, Bea, Pelgrom, Jolanda, Van Wanzeele, Filip, Verhofstede, Chris, Vandijck, Dominique M.
• Format: Journal Article
• Language: English
• Published: Switzerland International AIDS Society 12.12.2013; John Wiley & Sons, Inc
• Subjects: Acquired immune deficiency syndrome; Adult; Age; AIDS; AIDS (Disease); AIDS/HIV; Antiretroviral agents; Antiretroviral Therapy, Highly Active; Belgium; Care and treatment; Chronic diseases; Chronic fatigue syndrome; Chronic illnesses; Coping; Data collection; Depression - epidemiology; Drug therapy; Economic aspects; Employment; Female; Health aspects; Health surveys; Highly active antiretroviral therapy; HIV; HIV Infections - drug therapy; HIV Infections - psychology; HIV patients; Human immunodeficiency virus; Humans; Immune system; Infections; Male; Medication Adherence; Mental depression; Mental health; Middle Aged; MOS‐HIV; outcome; Patient compliance; Patient satisfaction; Population; Psychological aspects; Psychology; psychosocial; Public health; Quality of life; Quality of Life - psychology; Regression analysis; Social aspects; Social support; Socioeconomic Factors; Socioeconomics; Studies; Surveys and Questionnaires; Variables; Belgium; United Kingdom > UK; United States > US; AIDS; psychosocial; HIV; MOS-HIV; quality of life; outcome
• ISSN: 1758-2652; 1758-2652
• DOI: 10.7448/IAS.16.1.18643

Introduction Due to highly active antiretroviral therapy (HAART), HIV‐1 infection has evolved from a lethal to a chronic disease. As such, health‐related quality of life (HRQoL) has become an important outcome variable. The purpose of this study was to identify socio‐economic, behavioural, (neuro)psychological and clinical determinants of HRQoL among people living with HIV (PLHIV). Methods This study was conducted between 1 January and 31 December 2012 at the AIDS Reference Centre of Ghent University Hospital, a tertiary care referral centre in Belgium. Validated self‐report questionnaires were administered to collect socio‐demographic data, to assess HRQoL (Medical Outcomes Study‐HIV), depressive symptoms (Beck Depression Inventory‐II) and adherence to HAART (Short Medication Adherence Questionnaire) and to screen for neurocognitive dysfunction. Results A total of 237 people participated, among whom 187 (78.9%) were male. Mean age was 45.8±10.7 years and 144 (63.7%, 144/226) participants were homosexual. Median physical and mental health score (PHS, MHS) were 55.6 (IQR 48.2–60.6) and 52.0 (IQR 44.2–57.9), respectively. Multivariable regression analysis revealed that incapacity to work, depressive symptoms, neurocognitive complaints (NCCs), dissatisfaction with the patient–physician relationship and non‐adherence were all negatively associated with HRQoL. Conclusions Socio‐economic (work status), behavioural (adherence) and (neuro)psychological (depressive symptoms, NCCs) determinants independently impact HRQoL among this cohort of PLHIV. Clinical parameters (viral load, CD4 cell count) were not independently associated with HRQoL.