替吉奥联合经肝动脉化疗栓塞治疗中晚期肝细胞癌的疗效观察
目的对比观察经肝动脉栓塞化疗（TACE）单用或联合替吉奥治疗中晚期肝细胞癌（HCC）的疗效。方法将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组，每组30例。治疗组采用TACE联合替吉奥口服，对照组仅行TACE。观察2组的有效率、疾病控制率、生存率以及不良反应情况。计数资料采用，检验；生存分析运用Log—rank检验。结果有效率：治疗组63．3％，对照组33．3％，差异有统计学意义（z0=5．406，P=0．020）；疾病控制率：治疗组86．7％，对照组43．3％，差异有统计学意义（X2=12．308，P=0．000）。1年生存率：治疗组77．3％，...
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| Published in | 临床肝胆病杂志 Vol. 30; no. 1; pp. 55 - 57 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
广东省江门市新会区人民医院肿瘤血液科,广东江门,529100
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2014.01.012 |
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| Abstract | 目的对比观察经肝动脉栓塞化疗（TACE）单用或联合替吉奥治疗中晚期肝细胞癌（HCC）的疗效。方法将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组，每组30例。治疗组采用TACE联合替吉奥口服，对照组仅行TACE。观察2组的有效率、疾病控制率、生存率以及不良反应情况。计数资料采用，检验；生存分析运用Log—rank检验。结果有效率：治疗组63．3％，对照组33．3％，差异有统计学意义（z0=5．406，P=0．020）；疾病控制率：治疗组86．7％，对照组43．3％，差异有统计学意义（X2=12．308，P=0．000）。1年生存率：治疗组77．3％，对照组51．5％，差异有统计学意义（X2=4．593，P=0．032）；2年生存率：治疗组34．8％，对照组10．4％，差异有统计学意义（X2=4．812，P=0．028）。治疗组、对照组不良反应轻微，主要是恶心呕吐、腹泻和骨髓抑制，为1、2级，对症治疗可缓解，两组比较差异无统计学意义（P〉0．05）。结论替吉奥联合TACE术对中晚期HCC有一定的治疗价值，值得进一步探讨。 |
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| AbstractList | R735.7; 目的 对比观察经肝动脉栓塞化疗(TACE)单用或联合替吉奥治疗中晚期肝细胞癌(HCC)的疗效.方法 将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组,每组30例.治疗组采用TACE联合替吉奥口服,对照组仅行TACE.观察2组的有效率、疾病控制率、生存率以及不良反应情况.计数资料采用x2检验;生存分析运用Logrank检验.结果 有效率:治疗组63.3％,对照组33.3％,差异有统计学意义(x2=5.406,P=0.020);疾病控制率:治疗组86.7％,对照组43.3％,差异有统计学意义(x2=12.308,P=0.000).1年生存率:治疗组77.3％,对照组51.5％,差异有统计学意义(x2=4.593,P=0.032);2年生存率:治疗组34.8％,对照组10.4％,差异有统计学意义(x2=4.812,P=0.028).治疗组、对照组不良反应轻微,主要是恶心呕吐、腹泻和骨髓抑制,为1、2级,对症治疗可缓解,两组比较差异无统计学意义(P＞0.05).结论 替吉奥联合TACE术对中晚期HCC有一定的治疗价值,值得进一步探讨. 目的对比观察经肝动脉栓塞化疗（TACE）单用或联合替吉奥治疗中晚期肝细胞癌（HCC）的疗效。方法将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组，每组30例。治疗组采用TACE联合替吉奥口服，对照组仅行TACE。观察2组的有效率、疾病控制率、生存率以及不良反应情况。计数资料采用，检验；生存分析运用Log—rank检验。结果有效率：治疗组63．3％，对照组33．3％，差异有统计学意义（z0=5．406，P=0．020）；疾病控制率：治疗组86．7％，对照组43．3％，差异有统计学意义（X2=12．308，P=0．000）。1年生存率：治疗组77．3％，对照组51．5％，差异有统计学意义（X2=4．593，P=0．032）；2年生存率：治疗组34．8％，对照组10．4％，差异有统计学意义（X2=4．812，P=0．028）。治疗组、对照组不良反应轻微，主要是恶心呕吐、腹泻和骨髓抑制，为1、2级，对症治疗可缓解，两组比较差异无统计学意义（P〉0．05）。结论替吉奥联合TACE术对中晚期HCC有一定的治疗价值，值得进一步探讨。 |
| Author | 张呈 陈昌南 林云笑 苏铭俊 潘岐作 陈婵娟 容庭杰 谢峰 |
| AuthorAffiliation | 广东省江门市新会区人民医院肿瘤血液科,广东江门529100 |
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| ClassificationCodes | R735.7 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.3969/j.issn.1001-5256.2014.01.012 |
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| DocumentTitleAlternate | Clinical effect of transcatheter arterial chemoembolization combined with tegafur, gimeracii, and oteracil potassium in treatment of advanced hepatocellular carcinoma |
| DocumentTitle_FL | Clinical effect of transcatheter arterial chemoembolization combined with tegafur, gimeracil, and oteracil potassium in treatment of advanced hepatocellular carcinoma |
| EndPage | 57 |
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| Keywords | 化学栓塞,治疗性 chemoembolization,therapeutic carcinoma,hepatocellular gimeracil and oteracil porassium 替吉奥 癌,肝细胞 |
| Language | Chinese |
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| Notes | carcinoma, hepatocellular; chemoembolization, therapeutic ; gimeracil and oteracil porassium Objective To evaluate the clinical effect of transcatheter arterial chemoembolization （TACE） alone or combined with tegafur, gimeracil, and oteracil potassium （ S - 1 ） in the treatment of advanced hepatoeellular carcinoma （HCC）. Methods Sixty patients with un- resectable advanced HCC, who were admitted to our hospital from August 2009 to October 2010, were randomly divided into treatment group （ n = 30） and control group （ n = 30）. The treatment group was treated with TACE combined with oral S - 1, and the control group with TA- CE alone. The response rates, disease control rates, survival rates, and adverse reactions of both groups were evaluated. Categorical data were analyzed by chi - square test ; survival analysis was performed by Log - rank test. Results Compared with the control group, the treat- ment group had a significantly higher response rate （63.3 % vs 33.3 % , X2 = 5. 406, P = 0. 020） , a significantly h |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2014 |
| Publisher | 广东省江门市新会区人民医院肿瘤血液科,广东江门,529100 |
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| SubjectTerms | 化学栓塞 替吉奥 治疗性 癌 肝细胞 |
| Title | 替吉奥联合经肝动脉化疗栓塞治疗中晚期肝细胞癌的疗效观察 |
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