替吉奥联合经肝动脉化疗栓塞治疗中晚期肝细胞癌的疗效观察

目的对比观察经肝动脉栓塞化疗（TACE）单用或联合替吉奥治疗中晚期肝细胞癌（HCC）的疗效。方法将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组，每组30例。治疗组采用TACE联合替吉奥口服，对照组仅行TACE。观察2组的有效率、疾病控制率、生存率以及不良反应情况。计数资料采用，检验；生存分析运用Log—rank检验。结果有效率：治疗组63．3％，对照组33．3％，差异有统计学意义（z0=5．406，P=0．020）；疾病控制率：治疗组86．7％，对照组43．3％，差异有统计学意义（X2=12．308，P=0．000）。1年生存率：治疗组77．3％，...

Full description

Saved in:
Bibliographic Details
Published in临床肝胆病杂志 Vol. 30; no. 1; pp. 55 - 57
Main Author 张呈 陈昌南 林云笑 苏铭俊 潘岐作 陈婵娟 容庭杰 谢峰
Format Journal Article
LanguageChinese
Published 广东省江门市新会区人民医院肿瘤血液科,广东江门,529100 2014
Subjects
化学栓塞
替吉奥
治疗性
癌
肝细胞
化学栓塞,治疗性
chemoembolization,therapeutic
carcinoma,hepatocellular
gimeracil and oteracil porassium
替吉奥
癌,肝细胞
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.01.012

Cover

More Information
Summary:目的对比观察经肝动脉栓塞化疗（TACE）单用或联合替吉奥治疗中晚期肝细胞癌（HCC）的疗效。方法将2009年8月-2010年10月本院收治的无法手术切除的中晚期HCC患者60例随机分为2组，每组30例。治疗组采用TACE联合替吉奥口服，对照组仅行TACE。观察2组的有效率、疾病控制率、生存率以及不良反应情况。计数资料采用，检验；生存分析运用Log—rank检验。结果有效率：治疗组63．3％，对照组33．3％，差异有统计学意义（z0=5．406，P=0．020）；疾病控制率：治疗组86．7％，对照组43．3％，差异有统计学意义（X2=12．308，P=0．000）。1年生存率：治疗组77．3％，对照组51．5％，差异有统计学意义（X2=4．593，P=0．032）；2年生存率：治疗组34．8％，对照组10．4％，差异有统计学意义（X2=4．812，P=0．028）。治疗组、对照组不良反应轻微，主要是恶心呕吐、腹泻和骨髓抑制，为1、2级，对症治疗可缓解，两组比较差异无统计学意义（P〉0．05）。结论替吉奥联合TACE术对中晚期HCC有一定的治疗价值，值得进一步探讨。
Bibliography:carcinoma, hepatocellular; chemoembolization, therapeutic ; gimeracil and oteracil porassium
Objective To evaluate the clinical effect of transcatheter arterial chemoembolization （TACE） alone or combined with tegafur, gimeracil, and oteracil potassium （ S - 1 ） in the treatment of advanced hepatoeellular carcinoma （HCC）. Methods Sixty patients with un- resectable advanced HCC, who were admitted to our hospital from August 2009 to October 2010, were randomly divided into treatment group （ n = 30） and control group （ n = 30）. The treatment group was treated with TACE combined with oral S - 1, and the control group with TA- CE alone. The response rates, disease control rates, survival rates, and adverse reactions of both groups were evaluated. Categorical data were analyzed by chi - square test ; survival analysis was performed by Log - rank test. Results Compared with the control group, the treat- ment group had a significantly higher response rate （63.3 % vs 33.3 % , X2 = 5. 406, P = 0. 020） , a significantly h
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.01.012