An evaluation of a biopsychosocial framework for health-related quality of life and disability in rheumatoid arthritis

• Published in: Journal of psychosomatic research Vol. 71; no. 2; pp. 79 - 85
• Main Authors: Nicassio, Perry M, Kay, Morgan A, Custodio, Mara K, Irwin, Michael R, Olmstead, Richard, Weisman, Michael H
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2011; Elsevier
• Subjects: Adaptation, Psychological; Adult; Aged; Arthritis, Rheumatoid - psychology; Biological and medical sciences; Coping; Disability; Disability Evaluation; Disabled Persons; Diseases of the osteoarticular system; Female; Fundamental and applied biological sciences. Psychology; Health Status; Health-related quality of life; Humans; Illness and personality; Illness, stress and coping; Inflammatory joint diseases; Male; Medical sciences; Middle Aged; Models, Psychological; Psychiatry; Psychological factors; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Quality of Life; Rheumatoid arthritis; Severity of Illness Index; Stress; Health-related quality of life; Psychological factors; Rheumatoid arthritis; Handicap; Human; Immunopathology; Evaluation; Hope hopelessness; Diseases of the osteoarticular system; Autoimmune disease; Inflammatory joint disease; Biopsychosocial model; Psychosocial factor; Health-Related Quality of Life; Stress; Disability; Chronic; Coping
• ISSN: 0022-3999; 1879-1360
• DOI: 10.1016/j.jpsychores.2011.01.008

Abstract Objective To examine the relationships between physical, psychological, and social factors and health-related quality of life (HRQOL) and disability in rheumatoid arthritis (RA). Methods A sample of 106 patients with rheumatoid arthritis (RA) completed measures of self-reported disease activity and psychosocial functioning, including coping, personal mastery, social network, perceived stress, illness beliefs, the SF-36 and Health Assessment Questionnaire Disability Index (HAQ-DI). In addition, physician-based assessment of disease activity using the Disease Activity Scale (DAS-28) was obtained. Hierarchical multiple regression analyses were used to evaluate the relationships between psychosocial factors and scores on the SF-36 and HAQ-DI. Results Lower self-reported disease activity was associated with higher SF-36 physical functioning scores, while the contribution of active coping, passive coping, and helplessness was significant only as a block. Lower self-reported disease activity, higher personal mastery, and lower perceived stress contributed to higher SF-36 mental health functioning, and higher self-reported disease activity and lower helplessness were associated with greater disability, as indexed by the HAQ-DI. The DAS-28, an objective of measure of disease activity, was unrelated to any of these outcomes. Conclusions The findings highlight the importance of targeting psychological factors to enhance HRQOL and disability in the clinical management of RA patients.