Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases

• Published in: Aging and disease Vol. 8; no. 6; pp. 721 - 739
• Main Authors: Zhao, Haiping, Han, Ziping, Li, Guangwen, Zhang, Sijia, Luo, Yumin
• Format: Journal Article
• Language: English
• Published: United States JKL International 01.12.2017; JKL International LLC
• Subjects: Cancer; Herbal medicine; Inflammation; Life expectancy; Nervous system diseases; Review; Panax notoginseng; cancer; neurodegenerative disease; aging; vessel
• ISSN: 2152-5250; 2152-5250
• DOI: 10.14336/ad.2017.0724

Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic. In recent years, with the deepening of the research pharmacologically, many new functions have been discovered. This review will introduce its pharmacological function on lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer properties, aiming to lay the ground for fully elucidating the potential mechanisms of anti-aging effect to promote its clinical application.