Effects of Diet Soda on Gut Hormones in Youths With Diabetes

• Published in: Diabetes care Vol. 35; no. 5; pp. 959 - 964
• Main Authors: Brown, Rebecca J, Walter, Mary, Rother, Kristina I
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2012
• Subjects: acesulfame potassium; Adolescent; Adult; adverse effects; Analysis; Artificial sweeteners; Biological and medical sciences; Blood Glucose; Blood Glucose - drug effects; Blood Glucose - metabolism; Bottled water industry; c-peptide; C-Peptide - metabolism; Carbonated Beverages; Carbonated Beverages - adverse effects; Carbonates; Child; Cross-Over Studies; Diabetes; Diabetes Mellitus; Diabetes Mellitus - metabolism; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Diabetics; Diet; Diet therapy; digestive system; drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gastric Inhibitory Polypeptide; Gastric Inhibitory Polypeptide - metabolism; Gastrointestinal Hormones; Gastrointestinal Hormones - metabolism; glucagon-like peptide 1; Glucagon-Like Peptide 1 - metabolism; Glucose; Glucose - pharmacology; Hormones; Humans; ingestion; Insulin; insulin-dependent diabetes mellitus; Male; Medical sciences; Metabolic diseases; metabolism; Miscellaneous; noninsulin-dependent diabetes mellitus; nutrients; Original Research; patients; Peptide YY; Peptide YY - metabolism; Peptides; pharmacology; Public health. Hygiene; Public health. Hygiene-occupational medicine; secretion; Sucralose; Teenagers; Type 2 diabetes; Young Adult; Youth; Endocrinopathy; Human; Hormone; Nutrition; Digestive system; Diabetes mellitus; Gut; Metabolic diseases; Feeding; Carbonated beverage; Diet; Adolescent; Endocrinology

OBJECTIVE: In patients with type 2 diabetes, but not type 1 diabetes, abnormal secretion of incretins in response to oral nutrients has been described. In healthy youths, we recently reported accentuated glucagon-like peptide 1 (GLP-1) secretion in response to a diet soda sweetened with sucralose an...